4-Phenyl-5-[4-(quinolin-2-ylmethoxy)-phenyl]-pentanoic acid methyl ester

Base Information

Chemical Name:4-Phenyl-5-[4-(quinolin-2-ylmethoxy)-phenyl]-pentanoic acid methyl ester
CAS No.:129650-31-3
Molecular Formula:C₂₈H₂₇NO₃
Molecular Weight:425.527
Hs Code.:

Synonyms:4-Phenyl-5-[4-(quinolin-2-ylmethoxy)-phenyl]-pentanoic acid methyl ester

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Chemical Property of 4-Phenyl-5-[4-(quinolin-2-ylmethoxy)-phenyl]-pentanoic acid methyl ester

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Technology Process of 4-Phenyl-5-[4-(quinolin-2-ylmethoxy)-phenyl]-pentanoic acid methyl ester

There total 7 articles about 4-Phenyl-5-[4-(quinolin-2-ylmethoxy)-phenyl]-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 4377-41-7
2-Chloromethylquinoline

: 129649-91-8
methyl 5-(4-hydroxyphenyl)-4-phenylpentanoate

: 129650-31-3
4-Phenyl-5-[4-(quinolin-2-ylmethoxy)-phenyl]-pentanoic acid methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; acetone; for 72h; Heating;
DOI:10.1021/jm00172a024

Reference yield:

: 129649-56-5
3-<4-(benzyloxy)phenyl>-2-phenylpropanal

: 129650-31-3
4-Phenyl-5-[4-(quinolin-2-ylmethoxy)-phenyl]-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / tetrahydrofuran / 18 h

2: 87 percent / H₂ / 10percent Pd/C / ethanol; ethyl acetate / 2585.7 Torr

3: 95 percent / K₂CO₃ / acetone; dimethylformamide / 72 h / Heating

With hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00172a024

Reference yield:

: 304024-15-5
ethyl 3-<4-(benzyloxy)phenyl>-2-phenylpropionate

: 129650-31-3
4-Phenyl-5-[4-(quinolin-2-ylmethoxy)-phenyl]-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / 1 M LiAlH₄ / tetrahydrofuran / 0.5 h / Heating

2: 95 percent / pyridinium chlorochromate (PCC) / CH₂Cl₂ / 4.5 h

3: 76 percent / tetrahydrofuran / 18 h

4: 87 percent / H₂ / 10percent Pd/C / ethanol; ethyl acetate / 2585.7 Torr

5: 95 percent / K₂CO₃ / acetone; dimethylformamide / 72 h / Heating

With lithium aluminium tetrahydride; hydrogen; potassium carbonate; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00172a024