Methylene-ortho-chloroaniline

Base Information

• Chemical Name: Methylene-ortho-chloroaniline
• CAS No.: 82925-50-6
• Molecular Formula: C₇H₆ClN
• Molecular Weight: 139.584
• Mol file: 82925-50-6.mol

Synonyms:Methylene-ortho-chloroaniline

Chemical Property of Methylene-ortho-chloroaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of Methylene-ortho-chloroaniline

There total 1 articles about Methylene-ortho-chloroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + o-chloroaniline (95-51-2) → Methylene-ortho-chloroaniline (82925-50-6)

Guidance literature:

With sodium methylate; In methanol;

DOI:10.3987/COM-14-S(K)57

Reference yield:

Methylene-ortho-chloroaniline (82925-50-6) → N-methyl-2-chloroaniline (932-32-1)

Guidance literature:

With sodium tetrahydroborate;

DOI:10.3987/COM-14-S(K)57

Reference yield:

Methylene-ortho-chloroaniline (82925-50-6) → 3-(2-chlorophenyl)-4-phenyl-1-tosylimidazolidine

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / 2 h / 0 °C / Reflux

2.1: copper(II) bis(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 1 h / 60 °C

2.2: 5 h / 60 °C

With sodium tetrahydroborate; copper(II) bis(trifluoromethanesulfonate); In 1,2-dichloro-ethane;

DOI:10.1021/acs.orglett.6b03458

upstream raw materials:

formaldehyd

o-chloroaniline

Downstream raw materials:

N-methyl-2-chloroaniline