2-(naphthalen-1-ylethynyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

Base Information

• Chemical Name: 2-(naphthalen-1-ylethynyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole
• CAS No.: 1374348-21-6
• Molecular Formula: C₂₁H₁₁F₃N₂O
• Molecular Weight: 364.326
• Mol file: 1374348-21-6.mol

Synonyms:2-(naphthalen-1-ylethynyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

Chemical Property of 2-(naphthalen-1-ylethynyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(naphthalen-1-ylethynyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

There total 3 articles about 2-(naphthalen-1-ylethynyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole (477886-85-4) + 1-(2,2-dibromovinyl)naphthalene (77295-63-7) → 2-(naphthalen-1-ylethynyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole (1374348-21-6)

Guidance literature:

With copper(I) bromide; lithium tert-butoxide; at 80 ℃; for 2h;

DOI:10.1002/ejoc.201101542

Reference yield: 52.0%

5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole (477886-85-4) + 3-(1-naphthyl)propiolic acid (4843-42-9) → 2-(naphthalen-1-ylethynyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole (1374348-21-6)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; palladium dichloride; silver(l) oxide; In toluene; at 80 ℃; for 10h;

DOI:10.1055/s-0036-1588115

Reference yield:

4-(trifluoromethyl)benzoic acid hydrazide (339-59-3) → 2-(naphthalen-1-ylethynyl)-5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole (1374348-21-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 120 °C

2: copper(I) bromide; lithium tert-butoxide / 2 h / 80 °C

With copper(I) bromide; lithium tert-butoxide;

DOI:10.1002/ejoc.201101542

upstream raw materials:

5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazole

1-(2,2-dibromovinyl)naphthalene

4-(trifluoromethyl)benzoic acid hydrazide

3-(1-naphthyl)propiolic acid