2-{3-[3-methylpiperidin-4-ylidenemethyl]phenoxy}-5-(trifluoromethyl)pyrimidine

Base Information

Chemical Name:2-{3-[3-methylpiperidin-4-ylidenemethyl]phenoxy}-5-(trifluoromethyl)pyrimidine
CAS No.:1191250-54-0
Molecular Formula:C₁₈H₁₈F₃N₃O
Molecular Weight:349.356
Hs Code.:

Synonyms:2-{3-[3-methylpiperidin-4-ylidenemethyl]phenoxy}-5-(trifluoromethyl)pyrimidine

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Chemical Property of 2-{3-[3-methylpiperidin-4-ylidenemethyl]phenoxy}-5-(trifluoromethyl)pyrimidine

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Technology Process of 2-{3-[3-methylpiperidin-4-ylidenemethyl]phenoxy}-5-(trifluoromethyl)pyrimidine

There total 7 articles about 2-{3-[3-methylpiperidin-4-ylidenemethyl]phenoxy}-5-(trifluoromethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1190843-58-3
tert-butyl 4-(3-hydroxybenzylidene)-3-methylpiperidine-1-carboxylate

: 69034-12-4,176214-12-3
5-(trifluoromethyl)pyrimidine

: 1191250-54-0
2-{3-[3-methylpiperidin-4-ylidenemethyl]phenoxy}-5-(trifluoromethyl)pyrimidine

Guidance literature:: tert-butyl 4-(3-hydroxybenzylidene)-3-methylpiperidine-1-carboxylate; 5-(trifluoromethyl)pyrimidine; With caesium carbonate; In dimethyl sulfoxide; at 65 ℃; for 1h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 1191250-54-0
2-{3-[3-methylpiperidin-4-ylidenemethyl]phenoxy}-5-(trifluoromethyl)pyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / tetrahydrofuran / 1 h / 20 °C

2.1: methanol; sodium tetrahydroborate / 20 °C

3.1: 1H-imidazole; bromine; triphenylphosphine / dichloromethane / 0 - 20 °C

4.1: 4 h / 150 °C

5.1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

7.1: caesium carbonate / dimethyl sulfoxide / 1 h / 65 °C

7.2: 1 h / 20 °C

With pyridine; 1H-imidazole; methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; potassium tert-butylate; bromine; caesium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1190843-65-2
3-(hydroxymethyl)phenyl pivalate

: 1191250-54-0
2-{3-[3-methylpiperidin-4-ylidenemethyl]phenoxy}-5-(trifluoromethyl)pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole; bromine; triphenylphosphine / dichloromethane / 0 - 20 °C

2.1: 4 h / 150 °C

3.1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

5.1: caesium carbonate / dimethyl sulfoxide / 1 h / 65 °C

5.2: 1 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; potassium tert-butylate; bromine; caesium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;