(3β,18α,20β)-3-hydroxy-11-oxoolean-12-en-29-oic acid diphenylmethyl ester

Base Information

• Chemical Name: (3β,18α,20β)-3-hydroxy-11-oxoolean-12-en-29-oic acid diphenylmethyl ester
• CAS No.: 441759-67-7
• Molecular Formula: C₄₃H₅₆O₄
• Molecular Weight: 636.915
• Mol file: 441759-67-7.mol

Synonyms:(3β,18α,20β)-3-hydroxy-11-oxoolean-12-en-29-oic acid diphenylmethyl ester

Chemical Property of (3β,18α,20β)-3-hydroxy-11-oxoolean-12-en-29-oic acid diphenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3β,18α,20β)-3-hydroxy-11-oxoolean-12-en-29-oic acid diphenylmethyl ester

There total 2 articles about (3β,18α,20β)-3-hydroxy-11-oxoolean-12-en-29-oic acid diphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

18-α-glycyrrhetinic acid (1449-05-4) + diazodiphenylmethane (908093-98-1) → (3β,18α,20β)-3-hydroxy-11-oxoolean-12-en-29-oic acid diphenylmethyl ester (441759-67-7)

Guidance literature:

In methanol; diethyl ether; at 45 ℃;

DOI:10.1016/j.bmc.2009.10.036

Reference yield:

enoxolone (471-53-4) → (3β,18α,20β)-3-hydroxy-11-oxoolean-12-en-29-oic acid diphenylmethyl ester (441759-67-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / KOH / bis-(2-hydroxy-ethyl) ether / 2 h / 220 °C

With potassium hydroxide; In diethylene glycol;

DOI:10.1007/s706-002-8243-6

Reference yield: 31.1%

2,3,6,2',3',4',6'-hepta-O-acetyl-lactosyl bromide (4753-07-5) + (3β,18α,20β)-3-hydroxy-11-oxoolean-12-en-29-oic acid diphenylmethyl ester (441759-67-7) → diphenylmethyl 2',3',6',2'',3'',4'',6''-heptaacetyl-β-D-galactopyranosyl-(1->4)-β-D-glucopyranosyl-3-O-18α-glycyrrhetinate (441759-70-2)

Guidance literature:

With iodine; silver(l) oxide; In chloroform; at 20 ℃; for 48h;

DOI:10.1007/s706-002-8243-6

upstream raw materials:

18-α-glycyrrhetinic acid

diazodiphenylmethane

enoxolone

Downstream raw materials:

diphenylmethyl 2',3',6',2'',3'',4'',6''-heptaacetyl-β-D-galactopyranosyl-(1->4)-β-D-glucopyranosyl-3-O-18α-glycyrrhetinate