2-isobutyrylamino-7-[5-tert-butyldiphenylsilyl-2,3-bis-O-(methylthio)thiocarbonyl-β-D-ribofuranosyl]-5H-pyrrolo[3,2-d]pyrimidin-4-one

Base Information

Chemical Name:2-isobutyrylamino-7-[5-tert-butyldiphenylsilyl-2,3-bis-O-(methylthio)thiocarbonyl-β-D-ribofuranosyl]-5H-pyrrolo[3,2-d]pyrimidin-4-one
CAS No.:871231-54-8
Molecular Formula:C₃₅H₄₂N₄O₆S₄Si
Molecular Weight:771.091
Hs Code.:

Synonyms:2-isobutyrylamino-7-[5-tert-butyldiphenylsilyl-2,3-bis-O-(methylthio)thiocarbonyl-β-D-ribofuranosyl]-5H-pyrrolo[3,2-d]pyrimidin-4-one

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Chemical Property of 2-isobutyrylamino-7-[5-tert-butyldiphenylsilyl-2,3-bis-O-(methylthio)thiocarbonyl-β-D-ribofuranosyl]-5H-pyrrolo[3,2-d]pyrimidin-4-one

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Technology Process of 2-isobutyrylamino-7-[5-tert-butyldiphenylsilyl-2,3-bis-O-(methylthio)thiocarbonyl-β-D-ribofuranosyl]-5H-pyrrolo[3,2-d]pyrimidin-4-one

There total 4 articles about 2-isobutyrylamino-7-[5-tert-butyldiphenylsilyl-2,3-bis-O-(methylthio)thiocarbonyl-β-D-ribofuranosyl]-5H-pyrrolo[3,2-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 871231-53-7
2-isobutyrylamino-7-(5-tert-butyldiphenylsilyl-β-D-ribofuranosyl)-5H-pyrrolo[3,2-d]pyrimidin-4-one

: 75-15-0,12122-00-8
carbon disulfide

: 74-88-4
methyl iodide

: 871231-54-8
2-isobutyrylamino-7-[5-tert-butyldiphenylsilyl-2,3-bis-O-(methylthio)thiocarbonyl-β-D-ribofuranosyl]-5H-pyrrolo[3,2-d]pyrimidin-4-one

: 2-isobutyrylamino-5-methyl-7-[5-tert-butyldiphenylsilyl-2,3-bis-O-(methylthio)thiocarbonyl-β-D-ribofuranosyl]-5H-pyrrolo[3,2-d]pyrimidin-4-one

: 2-isobutyrylamino-5-(methylthio)thiocarbonyl-7-[5-tert-butyldiphenylsilyl-2,3-bis-O-(methylthio)thiocarbonyl-β-D-ribofuranosyl]-5H-pyrrolo[3,2-d]pyrimidin-4-one

Guidance literature:: With sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 1h;
DOI:10.1081/NCN-200051898

Reference yield:

: 864155-80-6
2-amino-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-5H-pyrrolo<3,2-d>pyrimidin-4(3H)-one

: 871231-54-8
2-isobutyrylamino-7-[5-tert-butyldiphenylsilyl-2,3-bis-O-(methylthio)thiocarbonyl-β-D-ribofuranosyl]-5H-pyrrolo[3,2-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaOMe / methanol / 4 h / 20 °C / pH 12

2.1: hexamethyldisilazane / dimethylformamide / 20 °C

2.2: 62 percent / pyridine / dimethylformamide / 24 h / 20 °C

3.1: 69 percent / imidazole / dimethylformamide

4.1: 37 percent / aq. NaOH / dimethylsulfoxide / 1 h / 20 °C

With 1H-imidazole; sodium hydroxide; sodium methylate; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1081/NCN-200051898

Reference yield:

: 102731-45-3
9-deazaguanosine

: 871231-54-8
2-isobutyrylamino-7-[5-tert-butyldiphenylsilyl-2,3-bis-O-(methylthio)thiocarbonyl-β-D-ribofuranosyl]-5H-pyrrolo[3,2-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hexamethyldisilazane / dimethylformamide / 20 °C

1.2: 62 percent / pyridine / dimethylformamide / 24 h / 20 °C

2.1: 69 percent / imidazole / dimethylformamide

3.1: 37 percent / aq. NaOH / dimethylsulfoxide / 1 h / 20 °C

With 1H-imidazole; sodium hydroxide; 1,1,1,3,3,3-hexamethyl-disilazane; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1081/NCN-200051898