(5'-fluoro-2',4-dihydroxy-1,1'-biphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

Base Information

Chemical Name:(5'-fluoro-2',4-dihydroxy-1,1'-biphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione
CAS No.:1416255-87-2
Molecular Formula:C₂₂H₁₅FO₂S₂
Molecular Weight:394.49
Hs Code.:

Synonyms:(5'-fluoro-2',4-dihydroxy-1,1'-biphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

Suppliers and Price of (5'-fluoro-2',4-dihydroxy-1,1'-biphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5'-fluoro-2',4-dihydroxy-1,1'-biphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (5'-fluoro-2',4-dihydroxy-1,1'-biphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

There total 5 articles about (5'-fluoro-2',4-dihydroxy-1,1'-biphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1416255-83-8
(5'-fluoro-2',4-dimethoxybiphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

: 1416255-87-2
(5'-fluoro-2',4-dihydroxy-1,1'-biphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

Guidance literature:: With boron tribromide; In dichloromethane; at -78 - 25 ℃; for 30h; Inert atmosphere;
DOI:10.1002/cbdv.201200275

Reference yield:

: 1416255-26-9
(5-bromo-2-methoxyphenyl)(2-methyl-1-benzothiophen-3-yl)methanone

: 1416255-87-2
(5'-fluoro-2',4-dihydroxy-1,1'-biphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 15 h / Reflux; Inert atmosphere

2: Lawessons reagent / toluene / 6 h / Reflux

3: boron tribromide / dichloromethane / 30 h / -78 - 25 °C / Inert atmosphere

With Lawessons reagent; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; boron tribromide; caesium carbonate; In 1,2-dimethoxyethane; dichloromethane; water; toluene; 1: |Suzuki Coupling;
DOI:10.1002/cbdv.201200275

Reference yield:

: 2476-35-9
5-bromo-2-methoxybenzoic acid

: 1416255-87-2
(5'-fluoro-2',4-dihydroxy-1,1'-biphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 3 h / Reflux

2: aluminum (III) chloride / dichloromethane / 0 - 25 °C

3: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 15 h / Reflux; Inert atmosphere

4: Lawessons reagent / toluene / 6 h / Reflux

5: boron tribromide / dichloromethane / 30 h / -78 - 25 °C / Inert atmosphere

With Lawessons reagent; aluminum (III) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; boron tribromide; caesium carbonate; In 1,2-dimethoxyethane; dichloromethane; water; toluene; 2: |Friedel-Crafts Acylation / 3: |Suzuki Coupling;
DOI:10.1002/cbdv.201200275