(5'-fluoro-2',4-dimethoxybiphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

Base Information

Chemical Name:(5'-fluoro-2',4-dimethoxybiphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione
CAS No.:1416255-83-8
Molecular Formula:C₂₄H₁₉FO₂S₂
Molecular Weight:422.544
Hs Code.:

Synonyms:(5'-fluoro-2',4-dimethoxybiphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

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Chemical Property of (5'-fluoro-2',4-dimethoxybiphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

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Technology Process of (5'-fluoro-2',4-dimethoxybiphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

There total 4 articles about (5'-fluoro-2',4-dimethoxybiphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1416255-41-8
(5'-fluoro-2',4-dimethoxy-1,1'-biphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanone

: 1416255-83-8
(5'-fluoro-2',4-dimethoxybiphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

Guidance literature:: With Lawessons reagent; In toluene; for 6h; Reflux;
DOI:10.1002/cbdv.201200275

Reference yield:

: 1416255-26-9
(5-bromo-2-methoxyphenyl)(2-methyl-1-benzothiophen-3-yl)methanone

: 1416255-83-8
(5'-fluoro-2',4-dimethoxybiphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 15 h / Reflux; Inert atmosphere

2: Lawessons reagent / toluene / 6 h / Reflux

With Lawessons reagent; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,2-dimethoxyethane; water; toluene; 1: |Suzuki Coupling;
DOI:10.1002/cbdv.201200275

Reference yield:

: 2476-35-9
5-bromo-2-methoxybenzoic acid

: 1416255-83-8
(5'-fluoro-2',4-dimethoxybiphenyl-3-yl)(2-methyl-1-benzothiophen-3-yl)methanethione

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 3 h / Reflux

2: aluminum (III) chloride / dichloromethane / 0 - 25 °C

3: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 15 h / Reflux; Inert atmosphere

4: Lawessons reagent / toluene / 6 h / Reflux

With Lawessons reagent; aluminum (III) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; thionyl chloride; caesium carbonate; In 1,2-dimethoxyethane; dichloromethane; water; toluene; 2: |Friedel-Crafts Acylation / 3: |Suzuki Coupling;
DOI:10.1002/cbdv.201200275