2-Allyl-6-methoxy-benzoic acid (1R,3S,4R)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-4-(4-methoxy-benzyloxy)-but-2-enyl]-4-methyl-hept-6-enyl ester

Base Information

Chemical Name:2-Allyl-6-methoxy-benzoic acid (1R,3S,4R)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-4-(4-methoxy-benzyloxy)-but-2-enyl]-4-methyl-hept-6-enyl ester
CAS No.:356548-43-1
Molecular Formula:C₃₇H₅₄O₆Si
Molecular Weight:622.918
Hs Code.:

Synonyms:2-Allyl-6-methoxy-benzoic acid (1R,3S,4R)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-4-(4-methoxy-benzyloxy)-but-2-enyl]-4-methyl-hept-6-enyl ester

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Chemical Property of 2-Allyl-6-methoxy-benzoic acid (1R,3S,4R)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-4-(4-methoxy-benzyloxy)-but-2-enyl]-4-methyl-hept-6-enyl ester

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Technology Process of 2-Allyl-6-methoxy-benzoic acid (1R,3S,4R)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-4-(4-methoxy-benzyloxy)-but-2-enyl]-4-methyl-hept-6-enyl ester

There total 15 articles about 2-Allyl-6-methoxy-benzoic acid (1R,3S,4R)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-4-(4-methoxy-benzyloxy)-but-2-enyl]-4-methyl-hept-6-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 325172-28-9
2-allyl-6-methoxy-benzoic acid

: 356548-44-2
(E)-(5S,7S,8R)-7-(tert-Butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-8-methyl-undeca-2,10-dien-5-ol

: 356548-43-1
2-Allyl-6-methoxy-benzoic acid (1R,3S,4R)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-4-(4-methoxy-benzyloxy)-but-2-enyl]-4-methyl-hept-6-enyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In benzene; at 20 ℃;

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 356548-43-1
2-Allyl-6-methoxy-benzoic acid (1R,3S,4R)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-4-(4-methoxy-benzyloxy)-but-2-enyl]-4-methyl-hept-6-enyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: 99 percent / 2,6-lutidine / -78 °C

2.1: 9-BBN / tetrahydrofuran / Heating

2.2: 84 percent / aq. NaOH; H₂O₂

3.1: 96 percent / DMSO; (COCl)2; Et₃N / -78 °C

4.1: 81 percent / NaHMDS / -78 - 20 °C

5.1: 90 percent / aq. TFA / CH₂Cl₂ / 20 °C

6.1: 81 percent / tosyl-imidazole; NaH

7.1: 94 percent / n-BuLi; BF₃*Et₂O / -78 °C

8.1: 96 percent / Ac₂O / 20 °C

9.1: 77 percent / LiAlH₄ / tetrahydrofuran / 20 °C

10.1: 91 percent / TBAI / dimethylformamide / 20 °C

11.1: 91 percent / AgNO₃; 2,6-lutidine / tetrahydrofuran / 20 °C

12.1: 84 percent / PPh₃; DEAD / benzene / 20 °C

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; oxalyl dichloride; boron trifluoride diethyl etherate; sodium hexamethyldisilazane; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; silver nitrate; dimethyl sulfoxide; triethylamine; triphenylphosphine; N-tosylimidazole; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene; 3.1: Swern oxidation / 4.1: Wittig methylenation;

Reference yield:

: 88440-84-0
N,N-Diethyl-2-allyl-6-methoxybenzamide

: 356548-43-1
2-Allyl-6-methoxy-benzoic acid (1R,3S,4R)-3-(tert-butyl-dimethyl-silanyloxy)-1-[(E)-4-(4-methoxy-benzyloxy)-but-2-enyl]-4-methyl-hept-6-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / I₂ / tetrahydrofuran; H₂O / 20 °C

2: 73 percent / Zn; AcOH / 90 °C

3: 84 percent / PPh₃; DEAD / benzene / 20 °C

With iodine; acetic acid; triphenylphosphine; zinc; diethylazodicarboxylate; In tetrahydrofuran; water; benzene;