3-chloro-4-[2-[[(1,1-dimethylethoxy)carbonyl]-amino]-ethylthio]benzeneacetic acid methyl ester

Base Information

• Chemical Name: 3-chloro-4-[2-[[(1,1-dimethylethoxy)carbonyl]-amino]-ethylthio]benzeneacetic acid methyl ester
• CAS No.: 393186-02-2
• Molecular Formula: C₁₆H₂₂ClNO₄S
• Molecular Weight: 359.874
• Mol file: 393186-02-2.mol

Synonyms:3-chloro-4-[2-[[(1,1-dimethylethoxy)carbonyl]-amino]-ethylthio]benzeneacetic acid methyl ester

Chemical Property of 3-chloro-4-[2-[[(1,1-dimethylethoxy)carbonyl]-amino]-ethylthio]benzeneacetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-chloro-4-[2-[[(1,1-dimethylethoxy)carbonyl]-amino]-ethylthio]benzeneacetic acid methyl ester

There total 6 articles about 3-chloro-4-[2-[[(1,1-dimethylethoxy)carbonyl]-amino]-ethylthio]benzeneacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-chloro-4-hydroxy-phenyl)-acetic acid (33697-81-3) → 3-chloro-4-[2-[[(1,1-dimethylethoxy)carbonyl]-amino]-ethylthio]benzeneacetic acid methyl ester (393186-02-2)

Guidance literature:

Multi-step reaction with 5 steps

1: Heating

2: DMAP; Et₃N / dioxane / 4 h / Heating

3: tetradecane / 5 h / 250 °C

4: NaOMe / methanol

5: methanol / 20 °C

With dmap; tetradecane; sodium methylate; triethylamine; In 1,4-dioxane; methanol;

DOI:10.1016/S0960-894X(01)00596-0

Reference yield:

(4-acetoxy-3-chloro-phenyl)-acetic acid methyl ester → 3-chloro-4-[2-[[(1,1-dimethylethoxy)carbonyl]-amino]-ethylthio]benzeneacetic acid methyl ester (393186-02-2)

Guidance literature:

Multi-step reaction with 4 steps

1: DMAP; Et₃N / dioxane / 4 h / Heating

2: tetradecane / 5 h / 250 °C

3: NaOMe / methanol

4: methanol / 20 °C

With dmap; tetradecane; sodium methylate; triethylamine; In 1,4-dioxane; methanol;

DOI:10.1016/S0960-894X(01)00596-0

Reference yield:

(3-chloro-4-dimethylthiocarbamoyloxyphenyl)acetic acid methyl ester (91373-91-0) → 3-chloro-4-[2-[[(1,1-dimethylethoxy)carbonyl]-amino]-ethylthio]benzeneacetic acid methyl ester (393186-02-2)

Guidance literature:

Multi-step reaction with 3 steps

1: tetradecane / 5 h / 250 °C

2: NaOMe / methanol

3: methanol / 20 °C

With tetradecane; sodium methylate; In methanol;

DOI:10.1016/S0960-894X(01)00596-0

upstream raw materials:

2-(tert-butoxycarbonylamino)ethyl-4-methylbenzenesulfonate

3-chloro-4-sulphanyl-phenylacetic acid methyl ester

(3-chloro-4-hydroxy-phenyl)-acetic acid

2-(N-tert-butoxycarbonylamino)ethanol