p-isopropylbenzaldehyde N-(tert-butoxycarbonyl)imine

Base Information

• Chemical Name: p-isopropylbenzaldehyde N-(tert-butoxycarbonyl)imine
• CAS No.: 1046828-42-5
• Molecular Formula: C₁₅H₂₁NO₂
• Molecular Weight: 247.337
• Mol file: 1046828-42-5.mol

Synonyms:p-isopropylbenzaldehyde N-(tert-butoxycarbonyl)imine

Chemical Property of p-isopropylbenzaldehyde N-(tert-butoxycarbonyl)imine

Chemical Property:

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Technology Process of p-isopropylbenzaldehyde N-(tert-butoxycarbonyl)imine

There total 2 articles about p-isopropylbenzaldehyde N-(tert-butoxycarbonyl)imine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[benzenesulfonyl-(4-isopropyl-phenyl)-methyl]-carbamic acid tert-butyl ester → p-isopropylbenzaldehyde N-(tert-butoxycarbonyl)imine (1046828-42-5)

Guidance literature:

With potassium carbonate; sodium sulfate; In tetrahydrofuran; for 16h; Inert atmosphere; Reflux;

DOI:10.1002/chem.201300241

Reference yield:

(4-isopropylbenzaldehyde) (122-03-2) → p-isopropylbenzaldehyde N-(tert-butoxycarbonyl)imine (1046828-42-5)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid / methanol; water / 24 h / 20 °C

2: potassium carbonate; sodium sulfate / tetrahydrofuran / 18 h / Inert atmosphere; Reflux

With formic acid; potassium carbonate; sodium sulfate; In tetrahydrofuran; methanol; water;

DOI:10.1021/acs.orglett.5b00934

Reference yield: 94.0%

p-isopropylbenzaldehyde N-(tert-butoxycarbonyl)imine (1046828-42-5) + Methyl thioglycolate (2365-48-2) → C18H27NO4S

Guidance literature:

With C₂₁H₂₃F₆N₃O₂; In dichloromethane; at -78 ℃; enantioselective reaction; Molecular sieve;

DOI:10.1039/c6ob01645f

upstream raw materials:

(4-isopropylbenzaldehyde)