Ethanone, 1-(3-fluorobicyclo[1.1.1]pent-1-yl)- (9CI)

Base Information

Chemical Name:Ethanone, 1-(3-fluorobicyclo[1.1.1]pent-1-yl)- (9CI)
CAS No.:262852-00-6
Molecular Formula:C₇H₉FO
Molecular Weight:128.146
Hs Code.:2912290090
Mol file:262852-00-6.mol

Synonyms:1-Acetyl-3-fluorobicyclo[1.1.1]pentane

Suppliers and Price of Ethanone, 1-(3-fluorobicyclo[1.1.1]pent-1-yl)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
1-(3-Fluorobicyclo[1.1.1]pentan-1-yl)ethan-1-one
1 g
$ 4560.00

American Custom Chemicals Corporation
1-(3-FLUOROBICYCLO[1.1.1]PENTAN-1-YL)ETHAN-1-ONE 95.00%
5MG
$ 450.88

ACHEMBLOCK
1-{3-fluorobicyclo[1.1.1]pentan-1-yl}ethan-1-one 97%
5G
$ 8135.00

Total 4 raw suppliers

Chemical Property of Ethanone, 1-(3-fluorobicyclo[1.1.1]pent-1-yl)- (9CI)

Chemical Property:

Boiling Point:147.6±40.0 °C(Predicted)
PSA：17.07000
Density:1.16±0.1 g/cm3(Predicted)
LogP:1.46760

Purity/Quality:

97% ^*data from raw suppliers

1-(3-Fluorobicyclo[1.1.1]pentan-1-yl)ethan-1-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Ethanone, 1-(3-fluorobicyclo[1.1.1]pent-1-yl)- (9CI)

There total 4 articles about Ethanone, 1-(3-fluorobicyclo[1.1.1]pent-1-yl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 3-fluoro-N-methoxy-N-methylbicyclo[1.1.1]pentane-1-carboxamide

: 75-16-1
methylmagnesium bromide

: 262852-00-6
1-(3-fluoro-1-bicyclo[1.1.1]pentanyl)ethanone

Guidance literature:: In tetrahydrofuran; at 0 - 5 ℃; for 5h;

Reference yield:

: 146038-53-1
3-fluorobicyclo<1.1.1>pentane-1-carboxylic acid

: 262852-00-6
1-(3-fluoro-1-bicyclo[1.1.1]pentanyl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C

2.1: tetrahydrofuran; diethyl ether / 2 h / -78 - -40 °C / Inert atmosphere

With oxalyl dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jacs.0c11964

Reference yield:

: 56842-95-6
bicyclo<1.1.1>pentane-1,3-dicarboxylic acid

: 262852-00-6
1-(3-fluoro-1-bicyclo[1.1.1]pentanyl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: Selectfluor; silver nitrate / water / 50 - 65 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide; 1,2-dichloro-ethane / 4 h / 20 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

3.1: tetrahydrofuran / 5 h / 0 - 5 °C

With silver nitrate; Selectfluor; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;