4-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]butanoic acid

Base Information

Chemical Name:4-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]butanoic acid
CAS No.:1606973-02-7
Molecular Formula:C₂₄H₂₃ClN₂O₂
Molecular Weight:406.912
Hs Code.:

Synonyms:4-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]butanoic acid

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Chemical Property of 4-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]butanoic acid

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Technology Process of 4-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]butanoic acid

There total 5 articles about 4-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1606976-47-9
methyl 4-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]butanoate

: 1606973-02-7
4-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]butanoic acid

Guidance literature:: methyl 4-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]butanoate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 1606973-02-7
4-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 1.5 h / Reflux

2: 1 h / 150 °C / Inert atmosphere

3: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

With lithium hydroxide monohydrate; sulfuric acid; water; In tetrahydrofuran;

Reference yield:

: 1187830-87-0
2,4-dichloro-6,7-dihydro-5H-cyclopenta[b]pyridine hydrochloric acid salt

: 1606973-02-7
4-[4-[[2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]amino]phenyl]butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; ethanol; water / 4 h / 90 °C / Inert atmosphere

2: 1 h / 150 °C / Inert atmosphere

3: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; potassium carbonate; In tetrahydrofuran; ethanol; water; toluene;