(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)phenyl)urea

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Chemical Name:(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)phenyl)urea
CAS No.:1429638-94-7
Molecular Formula:C₂₂H₂₇N₅O₂S
Molecular Weight:425.555
Hs Code.:

Synonyms:(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)phenyl)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)phenyl)urea

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Technology Process of (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)phenyl)urea

There total 2 articles about (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 874297-79-7
1-cyclopropyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea

: 1393712-35-0
(S)-2-chloro-4-(3-methylmorpholino)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine

: 1429638-94-7
(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,2-dimethoxyethane; water; at 70 ℃; Inert atmosphere;

Reference yield:

: 350595-57-2
(S)-3-methylmorpholine

: 181374-43-6
2,4-dichloro-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine

: 1429638-94-7
(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 70 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;