(2R,3R)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)pent-4-enyl]-3-methylcyclohex-3-enyl}-3-(4-methoxyphenoxy)pent-4-en-2-ol

Base Information

Chemical Name:(2R,3R)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)pent-4-enyl]-3-methylcyclohex-3-enyl}-3-(4-methoxyphenoxy)pent-4-en-2-ol
CAS No.:877066-08-5
Molecular Formula:C₃₆H₅₀O₇
Molecular Weight:594.789
Hs Code.:

Synonyms:(2R,3R)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)pent-4-enyl]-3-methylcyclohex-3-enyl}-3-(4-methoxyphenoxy)pent-4-en-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)pent-4-enyl]-3-methylcyclohex-3-enyl}-3-(4-methoxyphenoxy)pent-4-en-2-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R,3R)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)pent-4-enyl]-3-methylcyclohex-3-enyl}-3-(4-methoxyphenoxy)pent-4-en-2-ol

There total 10 articles about (2R,3R)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)pent-4-enyl]-3-methylcyclohex-3-enyl}-3-(4-methoxyphenoxy)pent-4-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 848760-91-8
{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enyl}-acetaldehyde

: 13391-35-0
allyl (4-methoxyphenyl) ether

: 877066-08-5
(2R,3R)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)pent-4-enyl]-3-methylcyclohex-3-enyl}-3-(4-methoxyphenoxy)pent-4-en-2-ol

: (2S,3S)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)pent-4-enyl]-3-methylcyclohex-3-enyl}-3-(4-methoxyphenoxy)pent-4-en-2-ol

Guidance literature:: allyl (4-methoxyphenyl) ether; With sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h;

With Ipc₂B(OMe); In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h;

{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enyl}-acetaldehyde; With boron trifluoride diethyl etherate; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃;
DOI:10.1002/chem.200500749

Reference yield:

: 848760-88-3
(2S,3R)-1-[(1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl]3-(4-methoxyphenoxy)-pent-4-en-2-ol

: 877066-08-5
(2R,3R)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)pent-4-enyl]-3-methylcyclohex-3-enyl}-3-(4-methoxyphenoxy)pent-4-en-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 95 percent / DIPEA; TBAI / CH₂Cl₂ / 25 °C

2.1: aq. LiBF₄ / acetonitrile / 25 °C

3.1: NaBH₄ / ethanol / 25 °C

4.1: 95 percent / TEA / CH₂Cl₂ / 0 - 25 °C

5.1: 100 percent / [18]crown-6 / acetonitrile / 80 °C

6.1: 100 percent / DIBAL-H / toluene; hexane / -78 °C

7.1: sec-BuLi / cyclohexane; tetrahydrofuran / 1 h / -78 °C

7.2: Ipc₂BOMe / cyclohexane; tetrahydrofuran / 1 h / -78 °C

7.3: 40 percent / BF₃*Et₂O / cyclohexane; tetrahydrofuran / -78 - 20 °C

With sodium tetrahydroborate; lithium tetrafluoroborate; 18-crown-6 ether; TEA; sec.-butyllithium; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; cyclohexane; toluene; acetonitrile;
DOI:10.1002/chem.200500749

Reference yield:

: 848760-89-4
1-{(R)-1-[(S)-2-((1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl)-1-methoxymethoxy-ethyl]-allyloxy}-4-methoxybenzene

: 877066-08-5
(2R,3R)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)pent-4-enyl]-3-methylcyclohex-3-enyl}-3-(4-methoxyphenoxy)pent-4-en-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: aq. LiBF₄ / acetonitrile / 25 °C

2.1: NaBH₄ / ethanol / 25 °C

3.1: 95 percent / TEA / CH₂Cl₂ / 0 - 25 °C

4.1: 100 percent / [18]crown-6 / acetonitrile / 80 °C

5.1: 100 percent / DIBAL-H / toluene; hexane / -78 °C

6.1: sec-BuLi / cyclohexane; tetrahydrofuran / 1 h / -78 °C

6.2: Ipc₂BOMe / cyclohexane; tetrahydrofuran / 1 h / -78 °C

6.3: 40 percent / BF₃*Et₂O / cyclohexane; tetrahydrofuran / -78 - 20 °C

With sodium tetrahydroborate; lithium tetrafluoroborate; 18-crown-6 ether; TEA; sec.-butyllithium; diisobutylaluminium hydride; In tetrahydrofuran; ethanol; hexane; dichloromethane; cyclohexane; toluene; acetonitrile;
DOI:10.1002/chem.200500749