2-(4-bromophenyl)but-3-en-2-yl tert-butyl carbonate

Base Information

Chemical Name:2-(4-bromophenyl)but-3-en-2-yl tert-butyl carbonate
CAS No.:1311260-03-3
Molecular Formula:C₁₅H₁₉BrO₃
Molecular Weight:327.218
Hs Code.:

Synonyms:2-(4-bromophenyl)but-3-en-2-yl tert-butyl carbonate

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Chemical Property of 2-(4-bromophenyl)but-3-en-2-yl tert-butyl carbonate

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Technology Process of 2-(4-bromophenyl)but-3-en-2-yl tert-butyl carbonate

There total 2 articles about 2-(4-bromophenyl)but-3-en-2-yl tert-butyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 51431-56-2
2-(4-bromophenyl)but-3-en-2-ol

: 1311260-03-3
2-(4-bromophenyl)but-3-en-2-yl tert-butyl carbonate

Guidance literature:: 2-(4-bromophenyl)but-3-en-2-ol; With potassium hydride; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

di-tert-butyl dicarbonate; In tetrahydrofuran; at -78 - 4 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jacs.0c02316

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1311260-03-3
2-(4-bromophenyl)but-3-en-2-yl tert-butyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2.1: potassium hydride / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 - 4 °C / Inert atmosphere

With potassium hydride; In tetrahydrofuran;
DOI:10.1021/ja2039248

Reference yield: 53.0%

: 1311260-03-3
2-(4-bromophenyl)but-3-en-2-yl tert-butyl carbonate

: 100-46-9
benzylamine

: C₁₇H₁₈BrN

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; (3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-(1-phenyl-ethyl)-amine; In tetrahydrofuran; acetonitrile; at 0 ℃; for 12h; enantioselective reaction;
DOI:10.1002/anie.201705825