2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (2,3-di-O-benzyl-4-desoxy-4-fluoro)-β-D-glucopyranoside

Base Information

Chemical Name:2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (2,3-di-O-benzyl-4-desoxy-4-fluoro)-β-D-glucopyranoside
CAS No.:1372809-39-6
Molecular Formula:C₃₉H₃₈F₄N₂O₆
Molecular Weight:706.734
Hs Code.:

Synonyms:2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (2,3-di-O-benzyl-4-desoxy-4-fluoro)-β-D-glucopyranoside

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Chemical Property of 2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (2,3-di-O-benzyl-4-desoxy-4-fluoro)-β-D-glucopyranoside

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Technology Process of 2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (2,3-di-O-benzyl-4-desoxy-4-fluoro)-β-D-glucopyranoside

There total 4 articles about 2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (2,3-di-O-benzyl-4-desoxy-4-fluoro)-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372809-47-6
C₄₅H₅₂F₄N₂O₆Si

: 1372809-39-6
2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (2,3-di-O-benzyl-4-desoxy-4-fluoro)-β-D-glucopyranoside

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 - 23 ℃; for 1.5h; Inert atmosphere;
DOI:10.3998/ark.5550190.0013.319

Reference yield:

: 1233840-30-6
2-benzyl-4-[(4-methoxybenzyl)]-5-trifluoromethyl-pyrazol-3-yl-2,3,6-tri-O-benzoyl-4-deoxy-4-fluoro-β-D-glucopyranoside

: 1372809-39-6
2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (2,3-di-O-benzyl-4-desoxy-4-fluoro)-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; sodium methylate / 2 h / 20 - 23 °C / Inert atmosphere

2.1: triethylamine; dmap / dichloromethane / 30 h / 20 - 23 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 0.75 h / 20 - 23 °C / Inert atmosphere

3.2: 4 h / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 - 23 °C / Inert atmosphere

With methanol; dmap; tetrabutyl ammonium fluoride; sodium methylate; sodium hydride; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.3998/ark.5550190.0013.319

Reference yield:

: 1372809-38-5
2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (4-desoxy-4-fluoro-6-O-tertbutyldimethylsilyl)-β-D-glucopyranoside

: 1372809-39-6
2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (2,3-di-O-benzyl-4-desoxy-4-fluoro)-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 0.75 h / 20 - 23 °C / Inert atmosphere

1.2: 4 h / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 - 23 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;
DOI:10.3998/ark.5550190.0013.319