2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (4-desoxy-4-fluoro-6-O-tertbutyldimethylsilyl)-β-D-glucopyranoside

Base Information

Chemical Name:2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (4-desoxy-4-fluoro-6-O-tertbutyldimethylsilyl)-β-D-glucopyranoside
CAS No.:1372809-38-5
Molecular Formula:C₃₁H₄₀F₄N₂O₆Si
Molecular Weight:640.748
Hs Code.:

Synonyms:2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (4-desoxy-4-fluoro-6-O-tertbutyldimethylsilyl)-β-D-glucopyranoside

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Chemical Property of 2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (4-desoxy-4-fluoro-6-O-tertbutyldimethylsilyl)-β-D-glucopyranoside

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Technology Process of 2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (4-desoxy-4-fluoro-6-O-tertbutyldimethylsilyl)-β-D-glucopyranoside

There total 2 articles about 2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (4-desoxy-4-fluoro-6-O-tertbutyldimethylsilyl)-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372809-37-4
C₂₅H₂₆F₄N₂O₆

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1372809-38-5
2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (4-desoxy-4-fluoro-6-O-tertbutyldimethylsilyl)-β-D-glucopyranoside

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 - 23 ℃; for 30h; regioselective reaction; Inert atmosphere;
DOI:10.3998/ark.5550190.0013.319

Reference yield:

: 1233840-30-6
2-benzyl-4-[(4-methoxybenzyl)]-5-trifluoromethyl-pyrazol-3-yl-2,3,6-tri-O-benzoyl-4-deoxy-4-fluoro-β-D-glucopyranoside

: 1372809-38-5
2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (4-desoxy-4-fluoro-6-O-tertbutyldimethylsilyl)-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; sodium methylate / 2 h / 20 - 23 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 30 h / 20 - 23 °C / Inert atmosphere

With methanol; dmap; sodium methylate; triethylamine; In dichloromethane;
DOI:10.3998/ark.5550190.0013.319

Reference yield:

: 1372809-38-5
2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (4-desoxy-4-fluoro-6-O-tertbutyldimethylsilyl)-β-D-glucopyranoside

: 100-39-0
benzyl bromide

: 1372809-47-6
C₄₅H₅₂F₄N₂O₆Si

Guidance literature:: 2-benzyl-4-(4-methoxybenzyl)-5-trifluoromethyl-2H-pyrazol-3-yl (4-desoxy-4-fluoro-6-O-tertbutyldimethylsilyl)-β-D-glucopyranoside; With sodium hydride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 20 - 23 ℃; for 0.75h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; for 4h; Inert atmosphere;
DOI:10.3998/ark.5550190.0013.319