(4R,4aR,8S,8aS)-3-Bromo-8-(tert-butyl-diphenyl-silanyloxy)-4-[2-((1R,2R)-2-furan-3-yl-1-methyl-5-oxo-cyclopentyl)-ethyl]-2,5-dioxo-octahydro-naphthalene-1,4a-dicarboxylic acid 1-tert-butyl ester 4a-methyl ester

Base Information

Chemical Name:(4R,4aR,8S,8aS)-3-Bromo-8-(tert-butyl-diphenyl-silanyloxy)-4-[2-((1R,2R)-2-furan-3-yl-1-methyl-5-oxo-cyclopentyl)-ethyl]-2,5-dioxo-octahydro-naphthalene-1,4a-dicarboxylic acid 1-tert-butyl ester 4a-methyl ester
CAS No.:448961-33-9
Molecular Formula:C₄₅H₅₅BrO₉Si
Molecular Weight:847.916
Hs Code.:

(4R,4aR,8S,8aS)-3-Bromo-8-(tert-butyl-diphenyl-silanyloxy)-4-[2-((1R,2R)-2-furan-3-yl-1-methyl-5-oxo-cyclopentyl)-ethyl]-2,5-dioxo-octahydro-naphthalene-1,4a-dicarboxylic acid 1-tert-butyl ester 4a-methyl ester

Synonyms:(4R,4aR,8S,8aS)-3-Bromo-8-(tert-butyl-diphenyl-silanyloxy)-4-[2-((1R,2R)-2-furan-3-yl-1-methyl-5-oxo-cyclopentyl)-ethyl]-2,5-dioxo-octahydro-naphthalene-1,4a-dicarboxylic acid 1-tert-butyl ester 4a-methyl ester

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Chemical Property of (4R,4aR,8S,8aS)-3-Bromo-8-(tert-butyl-diphenyl-silanyloxy)-4-[2-((1R,2R)-2-furan-3-yl-1-methyl-5-oxo-cyclopentyl)-ethyl]-2,5-dioxo-octahydro-naphthalene-1,4a-dicarboxylic acid 1-tert-butyl ester 4a-methyl ester

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Technology Process of (4R,4aR,8S,8aS)-3-Bromo-8-(tert-butyl-diphenyl-silanyloxy)-4-[2-((1R,2R)-2-furan-3-yl-1-methyl-5-oxo-cyclopentyl)-ethyl]-2,5-dioxo-octahydro-naphthalene-1,4a-dicarboxylic acid 1-tert-butyl ester 4a-methyl ester

There total 1 articles about (4R,4aR,8S,8aS)-3-Bromo-8-(tert-butyl-diphenyl-silanyloxy)-4-[2-((1R,2R)-2-furan-3-yl-1-methyl-5-oxo-cyclopentyl)-ethyl]-2,5-dioxo-octahydro-naphthalene-1,4a-dicarboxylic acid 1-tert-butyl ester 4a-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 415928-19-7
(4S)-4-t-butyldiphenylsilyloxy-2-carbomethoxycyclohex-2-en-1-one

: 448961-04-4
(4Z,2'R,3'R)-4-t-butyl bromo-7-[3'-(3-furyl)-2'-methyl-1'-oxocyclopent-2'-yl]-3-oxohept-4-enoate

: 448961-33-9
(4R,4aR,8S,8aS)-3-Bromo-8-(tert-butyl-diphenyl-silanyloxy)-4-[2-((1R,2R)-2-furan-3-yl-1-methyl-5-oxo-cyclopentyl)-ethyl]-2,5-dioxo-octahydro-naphthalene-1,4a-dicarboxylic acid 1-tert-butyl ester 4a-methyl ester

Guidance literature:: With caesium carbonate; In dichloromethane; at 20 ℃;
DOI:10.1021/ol027125o

Reference yield:

: 448961-33-9
(4R,4aR,8S,8aS)-3-Bromo-8-(tert-butyl-diphenyl-silanyloxy)-4-[2-((1R,2R)-2-furan-3-yl-1-methyl-5-oxo-cyclopentyl)-ethyl]-2,5-dioxo-octahydro-naphthalene-1,4a-dicarboxylic acid 1-tert-butyl ester 4a-methyl ester

: 448961-30-6
(4S,5S,8R,9S,10S,13R,14S,17S)-methyl 4-t-butyldiphenylsilyloxy-1,7-dioxo-17-(3-furyl)-14-hydroxyandrostane-10-carboxylate methyl

Guidance literature:: Multi-step reaction with 3 steps

1: pTSA / benzene / Heating

2: 63 percent / SmI₂ / tetrahydrofuran / -20 °C

3: 90 percent / HCl / CH₂Cl₂

With hydrogenchloride; samarium diiodide; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/ol027125o