415928-19-7

Upstream product

• 448961-26-0 (4S,2'S)-methyl 4-t-butyldiphenylsilyloxy-1-(1'-hydroxybut-2'-yl)-aminocyclohex-2-ene-2-carboxylate 
• 448961-24-8 (4S)-4-t-butyldiphenylsilyloxy-2-carbomethoxycyclohexan-1-one 
• 448961-23-7 rac-4-t-butyldiphenylsilyloxy-2-carbomethoxycyclohexan-1-one 
• 130745-59-4 4-<(tert-Butyldiphenylsilyl)oxy>cyclohexanone 
• 448961-36-2 5-(tert-butyl-diphenyl-silanyloxy)-2-oxo-1-phenylselanyl-cyclohexanecarboxylic acid methyl ester 

Downstream Products

• 448961-06-6 (4S,5S,9R,10R,1'R,5'R)-methyl 8-bromo-4-t-butyldiphenylsilyloxy-1,7-dioxo-9-{2''-[5'-(3-furyl)-1'-methyl-2'-oxocyclopent-1'-yl]-eth-1''-yl}-decahydronaphthalene-10-carboxylate 
• 448961-30-6 (4S,5S,8R,9S,10S,13R,14S,17S)-methyl 4-t-butyldiphenylsilyloxy-1,7-dioxo-17-(3-furyl)-14-hydroxyandrostane-10-carboxylate methyl 
• 448961-29-3 (4S,5S,8S,9S,10S,13R,14S,17S)-methyl 4-t-butyldiphenylsilyloxy-1,7-dioxo-17-(3-furyl)-14-hydroxyandrostane-10-carboxylate 
• 415928-20-0 (4S,5R,8S,9R,10R,13S,14S,17S)-4-(tert-Butyl-diphenyl-silanyloxy)-17-methoxymethoxy-13-methyl-1,7-dioxo-hexadecahydro-cyclopenta[a]phenanthrene-10-carboxylic acid methyl ester 
• 502761-45-7 [4S-(4β,5β,9α,10β,13β,17β)]-4-(tert-butyldiphenylsilanyloxy)-17-methoxymethoxy-13-methyl-1,7-dioxo-1,2,3,4,5,6,7,9,11,12,13,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-10-carboxylic acid methyl ester 
• 502761-43-5 [4S-(4β,5β,9α,10β,13β,17β)]-17-(tert-butyldimethylsilanyloxy)-4-(tert-butyldiphenylsilanyloxy)-13-methyl-1,7-dioxo-1,2,3,4,5,6,7,9,11,12,13,15,16,17-tetradecahydro-cyclopenta[a]phenanthrene-10-carboxylic acid methyl ester 
• 493021-07-1 (4S,4aS,8S,8aS)-4-{(R)-1-Acetoxy-2-[(1R,2S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-5-oxo-cyclopentyl]-ethyl}-8-(tert-butyl-diphenyl-silanyloxy)-2,5-dioxo-octahydro-naphthalene-1,4a-dicarboxylic acid 1-allyl ester 4a-methyl ester 
• 448961-33-9 (4R,4aR,8S,8aS)-3-Bromo-8-(tert-butyl-diphenyl-silanyloxy)-4-[2-((1R,2R)-2-furan-3-yl-1-methyl-5-oxo-cyclopentyl)-ethyl]-2,5-dioxo-octahydro-naphthalene-1,4a-dicarboxylic acid 1-tert-butyl ester 4a-methyl ester 
• 415928-24-4 (4S,5S,8S,9S,10S,13S,14R,17S)-4-(tert-Butyl-diphenyl-silanyloxy)-17-hydroxy-13-methyl-1,7-dioxo-hexadecahydro-cyclopenta[a]phenanthrene-10-carboxylic acid methyl ester 

Relevant academic research and scientific papers

A convergent synthesis of the cardenolide skeleton: Intramolecular aldol condensation via reduction of α-bromoketones

Synthesis of the highly biologically valuable cardenolide backbone was achieved via anionic polycyclization. Bromoketone 18, obtained from double-Michael cycloaddition between cyclohexenone 14 and γ,δ-unsaturated β-ketoester 16, was efficiently aldolized under reductive conditions. The highly functionalized tetracyclic compound 52 is an important synthetic intermediate that is potentially amenable to natural cardenolide total synthesis.