ethyl 2-(4-(4-(5-nitro-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetate

Base Information

Chemical Name:ethyl 2-(4-(4-(5-nitro-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetate
CAS No.:1448669-99-5
Molecular Formula:C₂₃H₂₅N₃O₄
Molecular Weight:407.469
Hs Code.:

Synonyms:ethyl 2-(4-(4-(5-nitro-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetate

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Chemical Property of ethyl 2-(4-(4-(5-nitro-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetate

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Technology Process of ethyl 2-(4-(4-(5-nitro-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetate

There total 4 articles about ethyl 2-(4-(4-(5-nitro-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1448669-98-4
ethyl 2-(4-(4-formylphenyl)cyclohexyl)acetate

: 99-56-9
4-Nitrophenylene-1,2-diamine

: 1448669-99-5
ethyl 2-(4-(4-(5-nitro-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetate

Guidance literature:: With Oxone; In water; N,N-dimethyl-formamide; at 25 ℃; for 24h;
DOI:10.1016/j.bmcl.2013.05.081

Reference yield:

: 4894-75-1
1-phenyl-4-cyclohexanone

: 1448669-99-5
ethyl 2-(4-(4-(5-nitro-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C

1.2: 4 h / 0 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 18 h / 20 °C

3.1: titanium tetrachloride / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4.1: Oxone / N,N-dimethyl-formamide; water / 24 h / 25 °C

With palladium 10% on activated carbon; Oxone; hydrogen; titanium tetrachloride; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 1.1: |Horner-Wadsworth-Emmons Olefination - Still-Gennari Modification / 1.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmcl.2013.05.081

Reference yield:

: 115880-04-1
ethyl 2-(4-phenylcyclohexylidene)acetate

: 1448669-99-5
ethyl 2-(4-(4-(5-nitro-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 18 h / 20 °C

2: titanium tetrachloride / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3: Oxone / N,N-dimethyl-formamide; water / 24 h / 25 °C

With palladium 10% on activated carbon; Oxone; hydrogen; titanium tetrachloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.05.081