2-(2,2,2-Trifluoroethoxy)pyridine-4-carboxylic acid

Base Information

Chemical Name:2-(2,2,2-Trifluoroethoxy)pyridine-4-carboxylic acid
CAS No.:262296-01-5
Molecular Formula:C₈H₆F₃NO₃
Molecular Weight:221.136
Hs Code.:
European Community (EC) Number:822-144-0
DSSTox Substance ID:DTXSID60595942
Wikidata:Q82491054
Mol file:262296-01-5.mol

Synonyms:262296-01-5;2-(2,2,2-trifluoroethoxy)pyridine-4-carboxylic acid;2-(2,2,2-Trifluoroethoxy)isonicotinic acid;4-Pyridinecarboxylic acid, 2-(2,2,2-trifluoroethoxy)-;2-(2,2,2-TRIFLUOROETHOXY)-4-PYRIDINECARBOXYLIC ACID;SCHEMBL796410;DTXSID60595942;AKOS000206132;KS-7434;2-(2,2,2-Trifluoroethoxy)isonicotinicacid;DB-421866;CS-0226754;EN300-84962;2-(2,2,2-Trifluoroethoxy)-4-pyridinecarboxylicacid;Z319446990

Suppliers and Price of 2-(2,2,2-Trifluoroethoxy)pyridine-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(2,2,2-trifluoroethoxy)pyridine-4-carboxylicAcid
10mg
$ 45.00

Crysdot
2-(2,2,2-Trifluoroethoxy)isonicotinicacid 97%
1g
$ 513.00

American Custom Chemicals Corporation
2-(2,2,2-TRIFLUOROETHOXY)-4-PYRIDINECARBOXYLIC ACID 95.00%
5MG
$ 499.15

AK Scientific
2-(2,2,2-Trifluoroethoxy)pyridine-4-carboxylicacid
5g
$ 2450.00

AK Scientific
2-(2,2,2-Trifluoroethoxy)pyridine-4-carboxylicacid
2.5g
$ 1698.00

Total 5 raw suppliers

Chemical Property of 2-(2,2,2-Trifluoroethoxy)pyridine-4-carboxylic acid

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.478
Boiling Point:354.206°C at 760 mmHg
PKA:3.39±0.10(Predicted)
Flash Point:168.018°C
PSA：59.42000
Density:1.454g/cm³
LogP:1.72090
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:221.02997754
Heavy Atom Count:15
Complexity:232

Purity/Quality:

98%min ^*data from raw suppliers

2-(2,2,2-trifluoroethoxy)pyridine-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN=C(C=C1C(=O)O)OCC(F)(F)F

Technology Process of 2-(2,2,2-Trifluoroethoxy)pyridine-4-carboxylic acid

There total 5 articles about 2-(2,2,2-Trifluoroethoxy)pyridine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 262296-01-5
2-(2,2,2-trifluoroethoxy)isonicotinic acid

Guidance literature:

Reference yield: 79.0%

: 618446-30-3
2-(2,2,2-trifluoroethoxy)pyridine-4-carbonitrile

: 262296-01-5
2-(2,2,2-trifluoroethoxy)isonicotinic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; Reflux;
DOI:10.1021/acsmedchemlett.1c00135

Reference yield:

: 6313-54-8
2-chloroisonicotinic acid,

: 262296-01-5
2-(2,2,2-trifluoroethoxy)isonicotinic acid

Guidance literature:: 2-chloroisonicotinic acid,; With 2,2,2-trifluoroethanol; potassium tert-butylate; at 170 ℃; for 120h;

With hydrogenchloride; In water;