C₁₅H₂₂ClNOS

Base Information

• Chemical Name: C₁₅H₂₂ClNOS
• CAS No.: 1227798-67-5
• Molecular Formula: C₁₅H₂₂ClNOS
• Molecular Weight: 299.865
• Mol file: 1227798-67-5.mol

Synonyms:C₁₅H₂₂ClNOS

Chemical Property of C₁₅H₂₂ClNOS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₂₂ClNOS

There total 1 articles about C₁₅H₂₂ClNOS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-chloro-1-(4-methylphenyl)butan-1-one (38425-26-2) + (S)-2-methylpropane-2-sulfinamide (343338-28-3) → C15H22ClNOS (1227798-67-5)

Guidance literature:

With titanium(IV) tetraethanolate; In neat (no solvent); at 72 ℃; Inert atmosphere;

DOI:10.1021/jo4014386

Reference yield: 86.0%

C15H22ClNOS (1227798-67-5) → (R)-1-((S)-2-methyl-propane-2-sulfinyl)-2-(4-methylphenyl)-pyrrolidine (1218989-41-3)

Guidance literature:

With lithium triethylborohydride; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1039/b925209f

Reference yield:

C15H22ClNOS (1227798-67-5) → (S)-1-((S)-2-methyl-propane-2-sulfinyl)-2-(4-methylphenyl)-pyrrolidine (1207729-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; 2-Amino-2-methyl-1-propanol; isopropyl alcohol; potassium tert-butylate / 2 h / 50 °C / Molecular sieve; Inert atmosphere

2: potassium tert-butylate / isopropyl alcohol / 1 h / 50 °C / Inert atmosphere

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; potassium tert-butylate; 2-Amino-2-methyl-1-propanol; isopropyl alcohol; In isopropyl alcohol;

DOI:10.1021/jo4014386

upstream raw materials:

4-chloro-1-(4-methylphenyl)butan-1-one

(S)-2-methylpropane-2-sulfinamide

Downstream raw materials:

(R)-1-((S)-2-methyl-propane-2-sulfinyl)-2-(4-methylphenyl)-pyrrolidine

(S)-1-((S)-2-methyl-propane-2-sulfinyl)-2-(4-methylphenyl)-pyrrolidine

(S)-2-(4-methylphenyl)pyrrolidine

C₁₈H₁₉NO