Technology Process of Cyclopentanecarboxylic acid, 3-amino-2-bromo-, (1R,2R,3R)-rel- (9CI)
There total 5 articles about Cyclopentanecarboxylic acid, 3-amino-2-bromo-, (1R,2R,3R)-rel- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
acetic acid;
at 70 ℃;
for 5h;
DOI:10.1021/jm9904755
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / Br2 / CH2Cl2 / 1 h / 0 °C
2: 89 percent / 1,5-diazobicyclo[4.3.0]non-5-ene / 5 h / 120 °C
3: 98 percent / H2 / 10percent Pd/C / ethyl acetate / 2 h
4: aq. cerium(IV) ammonium nitrate / acetonitrile / 5 h
5: 4 N aq. HCl / acetic acid / 5 h / 70 °C
With
hydrogenchloride; ammonium cerium(IV) nitrate; DBN; hydrogen; bromine;
10percent Pd/C;
In
dichloromethane; acetic acid; ethyl acetate; acetonitrile;
1: Bromination / 2: Dehydrobromination / 3: Catalytic hydrogenation / 4: Oxidative debenzylation / 5: Hydrolysis;
DOI:10.1021/jm9904755
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 89 percent / 1,5-diazobicyclo[4.3.0]non-5-ene / 5 h / 120 °C
2: 98 percent / H2 / 10percent Pd/C / ethyl acetate / 2 h
3: aq. cerium(IV) ammonium nitrate / acetonitrile / 5 h
4: 4 N aq. HCl / acetic acid / 5 h / 70 °C
With
hydrogenchloride; ammonium cerium(IV) nitrate; DBN; hydrogen;
10percent Pd/C;
In
acetic acid; ethyl acetate; acetonitrile;
1: Dehydrobromination / 2: Catalytic hydrogenation / 3: Oxidative debenzylation / 4: Hydrolysis;
DOI:10.1021/jm9904755
