133636-61-0Relevant articles and documents
Synthesis of cyclic γ-amino acids for foldamers and peptide nanotubes
Rodriguez-Vazquez, Nuria,Salzinger, Stephan,Silva, Luis F.,Amorin, Manuel,Granja, Juan R.
, p. 3477 - 3493 (2013)
Cyclic γ-amino acids are molecular building blocks of great interest in peptide and foldamer chemistry, as they allow the preparation of new structures that are not found in Nature. In this paper, we describe the synthesis of cyclic γ-amino acids that have a cis relationship between the amino and the carboxylic acid groups. This arrangement, in most cases, induces the resulting peptides to adopt a flat conformation, which makes them appropriate for the design of foldamers that adopt β-sheet-type structures. We describe the synthesis of cyclic γ-amino acids that have a cis relationship between the amino and the carboxylic acid groups. This makes them suitable for the design of foldamers that adopt β-sheet-type structures.
Electrophilic Substitution of a 2-Azabicyclohept-5-en-3-one as a Potential Route to 3-Deoxycarbocyclic Nucleosides
Palmer, Christopher F.,Parry, Keith P.,Roberts, Stanley M.
, p. 484 - 486 (2007/10/02)
The γ-lactam 9 reacted with bromine in the presence of acetic acid or fluoride ion to give the 6,7-substituted 2-azanorbornan-3-ones 10 or 15 respectively.The latter compounds were converted into the cyclopentylamine derivatives 14 and 16 which represent
