(1r,3s,4s)-3-Amino-4-fluorocyclopentane-1-carboxylic acid

Base Information

Chemical Name:(1r,3s,4s)-3-Amino-4-fluorocyclopentane-1-carboxylic acid
CAS No.:262279-96-9
Molecular Formula:C₆H₁₀FNO₂
Molecular Weight:147.149
Hs Code.:
DSSTox Substance ID:DTXSID50433682
Nikkaji Number:J2.119.227I
Wikidata:Q82247885
ChEMBL ID:CHEMBL163117
Mol file:262279-96-9.mol

Synonyms:(1r,3s,4s)-3-amino-4-fluorocyclopentane-1-carboxylic acid;141765-38-0;CHEMBL163117;3-Amino-4-fluoro-cyclopentanecarboxylic acid;Cyclopentanecarboxylic acid, 3-amino-4-fluoro-, (1alpha,3alpha,4beta)- (9CI);262279-96-9;SCHEMBL691392;DTXSID50433682;BDBM50085233;AKOS006365789;Cyclopentanecarboxylic acid,3-amino-4-fluoro-,(1alpha,3alpha,4beta)-(9ci)

Suppliers and Price of (1r,3s,4s)-3-Amino-4-fluorocyclopentane-1-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of (1r,3s,4s)-3-Amino-4-fluorocyclopentane-1-carboxylic acid

Chemical Property:

PSA：63.32000
LogP:0.84670
XLogP3:-2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:147.06955672
Heavy Atom Count:10
Complexity:151

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(CC(C1N)F)C(=O)O
Isomeric SMILES:C1[C@H](C[C@@H]([C@H]1N)F)C(=O)O

Technology Process of (1r,3s,4s)-3-Amino-4-fluorocyclopentane-1-carboxylic acid

There total 11 articles about (1r,3s,4s)-3-Amino-4-fluorocyclopentane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133636-61-0
2-(4'-methoxybenzyl)-2-azabicyclo<2.2.1>hept-5-en-3-one

: 141765-38-0,262279-96-9
(1R,3S,4S)-3-Amino-4-fluoro-cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 43 percent / N-bromosuccinimide, NEt₃*3HF / CH₂Cl₂ / 96 h / 4 °C

2: 90 percent / AIBN, Bu₃SnH / benzene / 18 h / Heating

3: 87 percent / ceric ammonium nitrate / H₂O; acetonitrile / 6 h / Ambient temperature

4: HCl / 1 h / Heating

With hydrogenchloride; N-Bromosuccinimide; ammonium cerium(IV) nitrate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine tris(hydrogen fluoride); In dichloromethane; water; acetonitrile; benzene;

Reference yield:

: 49805-30-3
2-azabicyclo[2.2.1.]hept-5-en-3-one

: 141765-38-0,262279-96-9
(1R,3S,4S)-3-Amino-4-fluoro-cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1) LiN(SiMe₃)2, 2) Bu₄NI / 1) THF, -78 deg C, 30 min, 2a) DMF, -78 to RT, 2b) RT, 24h

2: 43 percent / N-bromosuccinimide, NEt₃*3HF / CH₂Cl₂ / 96 h / 4 °C

3: 90 percent / AIBN, Bu₃SnH / benzene / 18 h / Heating

4: 87 percent / ceric ammonium nitrate / H₂O; acetonitrile / 6 h / Ambient temperature

5: HCl / 1 h / Heating

With hydrogenchloride; N-Bromosuccinimide; ammonium cerium(IV) nitrate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; tetra-(n-butyl)ammonium iodide; triethylamine tris(hydrogen fluoride); lithium hexamethyldisilazane; In dichloromethane; water; acetonitrile; benzene;

Reference yield:

: 141765-36-8
6-exo-fluoro-2-(4'-methoxybenzyl)-2-azabicyclo<2.2.1>heptan-3-one

: 141765-38-0,262279-96-9
(1R,3S,4S)-3-Amino-4-fluoro-cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / ceric ammonium nitrate / H₂O; acetonitrile / 6 h / Ambient temperature

2: HCl / 1 h / Heating

With hydrogenchloride; ammonium cerium(IV) nitrate; In water; acetonitrile;