1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil

Base Information

Chemical Name:1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil
CAS No.:362607-80-5
Molecular Formula:C₁₇H₁₅F₃N₂O₆
Molecular Weight:400.311
Hs Code.:

Synonyms:1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil

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Chemical Property of 1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil

Chemical Property:

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Technology Process of 1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil

There total 7 articles about 1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 98-88-4
benzoyl chloride

: 362607-79-2
1-(2-deoxy-β-L-threo-pentofuranosyl)-5-(trifluoromethyl)uracil

: 362607-80-5
1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil

Guidance literature:: In pyridine; at 0 ℃;
DOI:10.1016/S0968-0896(01)00062-1

Reference yield:

: 54-20-6
5-trifluoromethyluracil

: 362607-80-5
1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil

Guidance literature:: Multi-step reaction with 5 steps

1.1: TMSOTf / 1,2-dichloro-ethane / 20 °C

2.1: NH₂NH₂*H₂O / acetic acid; pyridine / 20 °C

3.1: 4-dimethylaminopyridine; PhOC(S)Cl / acetonitrile / 20 °C

3.2: (Me₃Si)3SiH; azobisisobutyronitrile / dioxane / Heating

4.1: NH₃ / methanol / 20 °C

5.1: pyridine / 0 °C

With pyridine; dmap; trimethylsilyl trifluoromethanesulfonate; ammonia; hydrazine hydrate; phenylcarbonochloridothioate; In pyridine; methanol; acetic acid; 1,2-dichloro-ethane; acetonitrile; 1.1: Vorbrueggen reaction;
DOI:10.1081/NCN-100002502

Reference yield:

: 201287-82-3
1,2-di-O-acetyl-3,5-di-O-benzoyl-β-L-xylofuranosyle

: 362607-80-5
1-(5-O-benzoyl-2-deoxy-β-L-threo-pentofuranosyl)-5-trifluoromethyluracil

Guidance literature:: Multi-step reaction with 5 steps

1.1: TMSOTf / 1,2-dichloro-ethane / 20 °C

2.1: NH₂NH₂*H₂O / acetic acid; pyridine / 20 °C

3.1: 4-dimethylaminopyridine; PhOC(S)Cl / acetonitrile / 20 °C

3.2: (Me₃Si)3SiH; azobisisobutyronitrile / dioxane / Heating

4.1: NH₃ / methanol / 20 °C

5.1: pyridine / 0 °C

With pyridine; dmap; trimethylsilyl trifluoromethanesulfonate; ammonia; hydrazine hydrate; phenylcarbonochloridothioate; In pyridine; methanol; acetic acid; 1,2-dichloro-ethane; acetonitrile; 1.1: Vorbrueggen reaction;
DOI:10.1081/NCN-100002502