methyl (2R)-2-(benzyloxycarbonylamino)-6-(phenylcarbonyloxyamino)hexanoate

Base Information

Chemical Name:methyl (2R)-2-(benzyloxycarbonylamino)-6-(phenylcarbonyloxyamino)hexanoate
CAS No.:937244-44-5
Molecular Formula:C₂₂H₂₆N₂O₆
Molecular Weight:414.458
Hs Code.:

Synonyms:methyl (2R)-2-(benzyloxycarbonylamino)-6-(phenylcarbonyloxyamino)hexanoate

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Chemical Property of methyl (2R)-2-(benzyloxycarbonylamino)-6-(phenylcarbonyloxyamino)hexanoate

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Technology Process of methyl (2R)-2-(benzyloxycarbonylamino)-6-(phenylcarbonyloxyamino)hexanoate

There total 2 articles about methyl (2R)-2-(benzyloxycarbonylamino)-6-(phenylcarbonyloxyamino)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70671-54-4
N^α-carbobenzoxy-D-lysine

: 937244-44-5
methyl (2R)-2-(benzyloxycarbonylamino)-6-(phenylcarbonyloxyamino)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 4.25 h / 0 - 20 °C

2: 3.262 g / 4 h / 20 °C / pH 10.5

With thionyl chloride;
DOI:10.1021/ol070382e

Reference yield:

: 188625-18-5
(R)-6-Amino-2-benzyloxycarbonylamino-hexanoic acid methyl ester

: 94-36-0
dibenzoyl peroxide

: 937244-44-5
methyl (2R)-2-(benzyloxycarbonylamino)-6-(phenylcarbonyloxyamino)hexanoate

Guidance literature:: at 20 ℃; for 4h; pH=10.5;
DOI:10.1021/ol070382e

Reference yield:

: 937244-44-5
methyl (2R)-2-(benzyloxycarbonylamino)-6-(phenylcarbonyloxyamino)hexanoate

: (R)-methyl 6-(N-(hydroxy)formamido)-2-(2-(2-hydroxyphenyl)-5-methyloxazole-4-carboxamido)hexanoate

Guidance literature:: Multi-step reaction with 5 steps

1: EDC / CH₂Cl₂ / 3 h / 0 - 20 °C

2: 2.03 g / iPr₂NEt / methanol / 63 h / 20 °C

3: 100 percent / HBr / acetic acid; CH₂Cl₂ / 0.5 h / 20 °C

4: 61 percent / Et₃N; HOBt; EDC / acetonitrile / 20 °C

5: 89 percent / H₂ / Pd/C / methanol / 1.5 h / 20 °C / 760.05 Torr

With hydrogen bromide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; acetic acid; acetonitrile;
DOI:10.1021/ol070382e