3-chloro-5-(4-phenoxyphenyl)isonicotinonilrile

Base Information

• Chemical Name: 3-chloro-5-(4-phenoxyphenyl)isonicotinonilrile
• CAS No.: 1266161-17-4
• Molecular Formula: C₁₈H₁₁ClN₂O
• Molecular Weight: 306.751
• Mol file: 1266161-17-4.mol

Synonyms:3-chloro-5-(4-phenoxyphenyl)isonicotinonilrile

Chemical Property of 3-chloro-5-(4-phenoxyphenyl)isonicotinonilrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-chloro-5-(4-phenoxyphenyl)isonicotinonilrile

There total 2 articles about 3-chloro-5-(4-phenoxyphenyl)isonicotinonilrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-phenoxyphenylboronic acid (51067-38-0) + 3,5-dichloropyridine-4-carbonitrile (153463-65-1) → 3-chloro-5-(4-phenoxyphenyl)isonicotinonilrile (1266161-17-4)

Guidance literature:

With potassium phosphate; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; for 20h; Inert atmosphere; Sealed tube; Reflux;

Reference yield:

3-phenoxyphenylboronic acid (221006-66-2) + 3,5-dichloropyridine-4-carbonitrile (153463-65-1) → 3-chloro-5-(4-phenoxyphenyl)isonicotinonilrile (1266161-17-4)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 110 ℃; Inert atmosphere;

Reference yield: 69.0%

3-chloro-5-(4-phenoxyphenyl)isonicotinonilrile (1266161-17-4) → 3-fluoro-5-(4-phenoxyphenyl)isonicotinonitrile (1266161-20-9)

Guidance literature:

With potassium fluoride; In dimethyl sulfoxide; at 120 ℃; for 240h;

upstream raw materials:

4-phenoxyphenylboronic acid

3,5-dichloropyridine-4-carbonitrile

3-phenoxyphenylboronic acid

Downstream raw materials:

3-fluoro-5-(4-phenoxyphenyl)isonicotinonitrile

C₁₈H₁₁FN₂O₂

3-chloro-4-cyano-5-(4-phenoxyphenyl)pyridine 1-oxide

3-chloro-2-(4-methoxyphenyl)-5-(4-phenoxyphenyl)isonicotinonitrile