153463-65-1

Usage

Uses

Used in Pharmaceutical Industry:
3,5-Dichloro-4-pyridinecarbonitrile is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a versatile building block for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 3,5-Dichloro-4-pyridinecarbonitrile serves as an essential intermediate for the production of agrochemicals. Its incorporation into these compounds contributes to the development of effective pesticides and other agricultural products designed to protect crops and enhance yield.
Used in Organic Chemistry Research:
3,5-Dichloro-4-pyridinecarbonitrile is utilized as a building block in organic chemistry research for the synthesis of a wide range of organic compounds. Its presence in these reactions enables the creation of novel molecules with potential applications in various fields, including materials science, pharmaceuticals, and agrochemicals.

Upstream product

• 183679-35-8 ethyl 3,5-dichloro-4-pyridinecarboximidate 
• 70593-51-0 3,5-dichloro-4-pyridine-carboxamide 
• 136590-83-5 3,5-dichloropyridine-4-carboxaldehyde 

Downstream Products

• 70593-51-0 3,5-dichloro-4-pyridine-carboxamide 
• 22889-78-7 3,5-dichloro-4-aminopyridine 
• 211571-70-9 5-Amino₃-chloro-4-cyanopyridine 
• 100868-46-0 3,5-dichloro-4-picoline 
• 402561-62-0 methyl 3,5-dichloro-4-pyridyl imine 
• 2457-47-8 3,5-dichloropyridine 
• 900863-37-8 1-[4-(5-chloro-4-cyanopyrid-3-yl)phenyl]-3-(2-fluoro-5-trifluoromethylphenyl)urea 
• 886457-32-5 3-(4-Amino-phenyl)-5-chloro-isonicotinonitrile 
• 402561-66-4 methyl 3,5-dichloro-4-pyridyl ketone 

Relevant academic research and scientific papers

Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors

Tumor angiogenesis is mediated by KDR and other VEGFR and PDGFR kinases. Their inhibition presents an attractive approach for developing anticancer therapeutics. Here, we report a series of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted k

CYANOPYRIDINE PESTICIDES

The present invention relates to cyanopyridine compounds of the general formula (I) and to the agriculturally useful salts thereof and to compositions comprising such compounds. The invention also relates to the use of the cyanopyridine compounds, of their salts or of compositions comprising them for combating animal pests. In formula (I) n is 0, 1 or 2; X is N, N-O or C-R4; Y is N, N-O or C-R5; Z is N, N-O or C-R6; with the proviso that one of the variables X, Y and Z is N or NO and the other two variables are optionally substituted carbon atoms; R1, R2 are, independently of one another, selected from the group consisting of hydrogen, C(=O)-R7, optionally subsitutetd C1-C10-alkyl, C2-C6-alkenyl, C2-C10-alkinyl, C1-C10-alkoxy or C3-C10-cycloalkyl, or R1 and R2 together with the adjacent nitrogen form a 3 to 10-membered ring, optionally substituted by 1, 2 or 3 radicals selected from C1-C5-alkyl and halogen, wherein the ring may contain, in addition to the nitrogen and carbon ring members, 1, 2 or 3 heteroatoms as ring members selected from the group consisting of nitrogen, oxygen, sulfur, a group SO, SO2 or N-R8; R3 is hydrogen, nitro, cyano, azido, amino, halogen, sulfonylamino, sulfenylamino, sulfinylamino, C(=O)R9, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, C3-C8- cycloalkyl, C1-C6-alkoxy, C1-C6-alkylthio, (C1-C6-alkyl)amino, di(C1-C6-alkyl)amino, C1-C6-alkylsulfinyl, or C1-C6-alkylsulfonyl, R4, R5 and R6 are independently of one another selected from the group consisting of hydrogen, halogen, cyano, azido, nitro, C1-C6-alkyl, C3-C8-cycloalkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl, C1-C4-alkylsulfonyl, C1-C4-haloalkoxy, C1-C4-haloalkylthio, C2-C6-alkenyl, C2-C6-alkinyl, (C1-C4-alkoxy)carbonyl, amino, (C1-C4-alkyl)amino, di(C1-C4-alkyl)amino, aminocarbonyl, (C1-C4-alkyl)aminocarbonyl, di(C1-C4-alkyl)aminocarbonyl, hydroxysulfonyl, sulfonylamino, sulfenylamino, sulfinylamino and C(=O)-R10.

ISOTHIAZOLOPYRIDIN-3-YLENAMINES FOR COMBATING ANIMAL PESTS

The present invention relates to lsothiazolopyridin-3-ylenamine compounds of the general formula I and to the agriculturally useful salts thereof and to compositions comprising such compounds. The invention also relates to the use of the lsothiazolopyridin-3-ylenamine compounds, of their salts or of compositions comprising them for combating animal pests. A lsothiazolopyridin-3-ylenamine compound of the present invention is represented by the following formula I:

THIOAMIDE COMPOUNDS FOR COMBATING ANIMAL PEST

The present invention relates to thioamide compounds of the general formula (I) and to the agriculturally useful salts thereof and to compositions comprising such compounds. The invention also relates to the use of the thioamide compounds, of their salts or of compositions comprising them for combating animal pests. wherein R1,R2, R3,R4,R6 and X are defined as in the description.

ANTAGONISTS OF THE MGLU RECEPTOR AND USES THEREOF

The present invention discloses compounds of general formula (I) wherein X1-X4 and R1-R3 are as defined in the description. The present invention also discloses methods of treatment for pain, neurodegeneration and convulsive states in a host mammal in need thereof, and pharmaceutical compositions including those compounds.

Novel kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists

SAR (structure-activity relationship) studies of triazafluorenone derivatives as potent mGluR1 antagonists are described. The triazafluorenone derivatives are non-amino acid derivatives and noncompetitive mGluR1 antagonists that bind at a putative alloste

FUROISOQUINOLINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

A compound having a partial structure represented by Formula: or a salt thereof has an excellent phosphodiesterase (PDE) IV-inhibiting effect, and is useful as a prophylactic or therapeutic agent against inflammatory diseases, for example, bronchial asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, autoimmune disease, diabetes and the like.

Cell adhesion-inhibiting antiinflammatory compounds

Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.

Convenient access to 3,4,5-trisubstituted pyridines

The reaction of 3,5-dichloro-4-pyridinecarbonitrile towards nucleophilic substitution of chlorine atoms and nucleophilic addition to the cyano group has been studied in presence of different nucleophiles and solvents in order to evidence the best conditions for the synthesis of 3,4,5-trifunctionalized pyridines. Besides the products of substitution of only one chlorine atom, 3,5-bis(ethylthio)-4-pyridinecarbonitrile and 3,5-bis(tert-butylthio)-4-pyridinecarbonitrile have been prepared in high yields and the reduction of their cyano to amino group has been studied in order to obtain model molecules and new selective inhibitors of extramitochondrial amine oxidase enzymes.