Technology Process of (2S,3R,5R)-7-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-2-methyl-4-methylene-heptane-3,5-diol
There total 8 articles about (2S,3R,5R)-7-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-2-methyl-4-methylene-heptane-3,5-diol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
bis(cyclopentadienyl)titanium dichloride; zinc(II) chloride; zinc;
In
tetrahydrofuran;
at 0 - 20 ℃;
DOI:10.1016/j.tet.2003.08.056
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: DIBAL-H
2.1: titanium(IV) chloride; diisopropylethylamine / CH2Cl2 / 0.33 h / 0 °C
2.2: 78 percent / CH2Cl2 / -78 - 0 °C
3.1: sodium borohydride / ethanol / 0.25 h / 0 °C
4.1: 6.68 g / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 4 h / 0 - 20 °C
5.1: titanium tetraisopropoxide; (-)-diisopropyl tartrate; tert-butyl hydroperoxide / molecular sieves 4 Angstroem / CH2Cl2; toluene / 3 h / -20 °C
6.1: 75 percent / bis(cyclopentadienyl)titanium(IV) dichloride; zinc; zinc chloride / tetrahydrofuran / 0 - 20 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; bis(cyclopentadienyl)titanium dichloride; sodium tetrahydroborate; (-)-diisopropyl tartrate; titanium tetrachloride; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; zinc;
4 A molecular sieve;
In
tetrahydrofuran; ethanol; dichloromethane; toluene;
4.2: aldol reaction / 7.1: Sharpless asymmetric epoxidation;
DOI:10.1016/j.tet.2003.08.056
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: DIBAL-H
2.1: titanium(IV) chloride; diisopropylethylamine / CH2Cl2 / 0.33 h / 0 °C
2.2: 78 percent / CH2Cl2 / -78 - 0 °C
3.1: sodium borohydride / ethanol / 0.25 h / 0 °C
4.1: 6.68 g / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 4 h / 0 - 20 °C
5.1: titanium tetraisopropoxide; (-)-diisopropyl tartrate; tert-butyl hydroperoxide / molecular sieves 4 Angstroem / CH2Cl2; toluene / 3 h / -20 °C
6.1: 75 percent / bis(cyclopentadienyl)titanium(IV) dichloride; zinc; zinc chloride / tetrahydrofuran / 0 - 20 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; bis(cyclopentadienyl)titanium dichloride; sodium tetrahydroborate; (-)-diisopropyl tartrate; titanium tetrachloride; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; zinc;
4 A molecular sieve;
In
tetrahydrofuran; ethanol; dichloromethane; toluene;
3.2: aldol reaction / 6.1: Sharpless asymmetric epoxidation;
DOI:10.1016/j.tet.2003.08.056
![(1R,2S)-1-[(2R,3R)-3-(2-Benzyloxy-ethyl)-2-methyl-oxiranyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propan-1-ol](/Databaselist/images/loading.webp)
