9H-fluoren-9-ylmethyl 5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]pentylcarbamate

Base Information

Chemical Name:9H-fluoren-9-ylmethyl 5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]pentylcarbamate
CAS No.:945534-37-2
Molecular Formula:C₄₇H₄₆N₄O₄
Molecular Weight:730.907
Hs Code.:

Synonyms:9H-fluoren-9-ylmethyl 5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]pentylcarbamate

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Chemical Property of 9H-fluoren-9-ylmethyl 5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]pentylcarbamate

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Technology Process of 9H-fluoren-9-ylmethyl 5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]pentylcarbamate

There total 5 articles about 9H-fluoren-9-ylmethyl 5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]pentylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₂H₃₄N₄O₃

: 606-83-7
3,3-Diphenylpropionic acid

: 945534-37-2
9H-fluoren-9-ylmethyl 5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]pentylcarbamate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm070246f

Reference yield:

: 945534-34-9
9H-fluoren-9-ylmethyl 5-[(4R)-4-[(tert-butoxycarbonyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]pentylcarbamate

: 945534-37-2
9H-fluoren-9-ylmethyl 5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]pentylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: aq. TFA / acetonitrile / 1 h / 20 °C

2: NEt₃; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jm070246f

Reference yield:

: 1026406-97-2
C₃₇H₄₄N₄O₆

: 945534-37-2
9H-fluoren-9-ylmethyl 5-[(4R)-4-[(3,3-diphenylpropanoyl)amino]-3-oxo-3,4,5,10-tetrahydroazepino[3,4-b]indol-2(1H)-yl]pentylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / acetonitrile; H₂O / 0 - 20 °C

2: aq. TFA / acetonitrile / 1 h / 20 °C

3: NEt₃; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 20 °C

With pyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; water; acetonitrile;
DOI:10.1021/jm070246f