1-[2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-cyclopropyl-2-(1,2,4-triazol-1-yl)ethanol

Base Information

Chemical Name:1-[2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-cyclopropyl-2-(1,2,4-triazol-1-yl)ethanol
CAS No.:1615663-85-8
Molecular Formula:C₁₉H₂₅BClN₃O₃
Molecular Weight:389.69
Hs Code.:

Synonyms:1-[2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-cyclopropyl-2-(1,2,4-triazol-1-yl)ethanol

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Chemical Property of 1-[2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-cyclopropyl-2-(1,2,4-triazol-1-yl)ethanol

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Technology Process of 1-[2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-cyclopropyl-2-(1,2,4-triazol-1-yl)ethanol

There total 4 articles about 1-[2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-cyclopropyl-2-(1,2,4-triazol-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1615663-83-6
1-(4-bromo-2-chloro-phenyl)-1-cyclopropyl-2-(1,2,4-triazol-1-yl)ethanol

: 73183-34-3
bis(pinacol)diborane

: 1615663-85-8
1-[2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-cyclopropyl-2-(1,2,4-triazol-1-yl)ethanol

Guidance literature:: With potassium acetate; In 1,4-dioxane; for 4h; Reflux;

Reference yield:

: 1400701-89-4
(4-bromo-2-chloro-phenyl)-cyclopropyl-methanone

: 1615663-85-8
1-[2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-cyclopropyl-2-(1,2,4-triazol-1-yl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 1 h

1.2: 48 h

2.1: sodium hydroxide / 1-methyl-pyrrolidin-2-one / 1 h / 120 °C

3.1: potassium acetate / 1,4-dioxane / 4 h / Reflux

With potassium tert-butylate; potassium acetate; sodium hydroxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dimethyl sulfoxide;

Reference yield:

: 31928-47-9
4-bromo-2-chloroiodobenzene

: 1615663-85-8
1-[2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-cyclopropyl-2-(1,2,4-triazol-1-yl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / -20 °C

1.2: 25 - 35 °C

2.1: potassium tert-butylate / dimethyl sulfoxide / 1 h

2.2: 48 h

3.1: sodium hydroxide / 1-methyl-pyrrolidin-2-one / 1 h / 120 °C

4.1: potassium acetate / 1,4-dioxane / 4 h / Reflux

With potassium tert-butylate; isopropylmagnesium chloride; potassium acetate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dimethyl sulfoxide;