dimethyl 2-[(4-but-2-ynyloxybenzenesulfonylamino)methyl]-2-piperazin-1-ylmalonate

Base Information

Chemical Name:dimethyl 2-[(4-but-2-ynyloxybenzenesulfonylamino)methyl]-2-piperazin-1-ylmalonate
CAS No.:1260170-74-8
Molecular Formula:C₂₀H₂₇N₃O₇S
Molecular Weight:453.516
Hs Code.:

Synonyms:dimethyl 2-[(4-but-2-ynyloxybenzenesulfonylamino)methyl]-2-piperazin-1-ylmalonate

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Chemical Property of dimethyl 2-[(4-but-2-ynyloxybenzenesulfonylamino)methyl]-2-piperazin-1-ylmalonate

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Technology Process of dimethyl 2-[(4-but-2-ynyloxybenzenesulfonylamino)methyl]-2-piperazin-1-ylmalonate

There total 8 articles about dimethyl 2-[(4-but-2-ynyloxybenzenesulfonylamino)methyl]-2-piperazin-1-ylmalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1260170-73-7
dimethyl 2-(4-tert-butoxycarbonylpiperazin-1-yl)-2-[(4-but-2-ynyloxybenzenesulfonylamino)methyl]malonate

: 1260170-74-8
dimethyl 2-[(4-but-2-ynyloxybenzenesulfonylamino)methyl]-2-piperazin-1-ylmalonate

Guidance literature:: dimethyl 2-(4-tert-butoxycarbonylpiperazin-1-yl)-2-[(4-but-2-ynyloxybenzenesulfonylamino)methyl]malonate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;

With sodium hydrogencarbonate; In dichloromethane; water; pH=8;

Reference yield:

: 4-but-2-ynyloxy-benzenesulfonic acid sodium salt

: 1260170-74-8
dimethyl 2-[(4-but-2-ynyloxybenzenesulfonylamino)methyl]-2-piperazin-1-ylmalonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 18 h / -10 - 20 °C

2.1: triethylamine / dichloromethane / 2 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

3.2: pH 8

With oxalyl dichloride; triethylamine; trifluoroacetic acid; N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

: 825-90-1
sodium p-hydroxybenzenesulfonate

: 1260170-74-8
dimethyl 2-[(4-but-2-ynyloxybenzenesulfonylamino)methyl]-2-piperazin-1-ylmalonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / isopropyl alcohol; water / 18 h / 70 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 18 h / -10 - 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

4.2: pH 8

With oxalyl dichloride; triethylamine; trifluoroacetic acid; sodium hydroxide; N,N-dimethyl-formamide; In dichloromethane; water; isopropyl alcohol;