dimethyl 2-{[(4-but-2-ynyloxybenzenesulfonyl)methylamino]methyl}-2-(4-methanesulfonylpiperazin-1-yl)malonate

Base Information

Chemical Name:dimethyl 2-{[(4-but-2-ynyloxybenzenesulfonyl)methylamino]methyl}-2-(4-methanesulfonylpiperazin-1-yl)malonate
CAS No.:1260170-76-0
Molecular Formula:C₂₂H₃₁N₃O₉S₂
Molecular Weight:545.635
Hs Code.:

Synonyms:dimethyl 2-{[(4-but-2-ynyloxybenzenesulfonyl)methylamino]methyl}-2-(4-methanesulfonylpiperazin-1-yl)malonate

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Chemical Property of dimethyl 2-{[(4-but-2-ynyloxybenzenesulfonyl)methylamino]methyl}-2-(4-methanesulfonylpiperazin-1-yl)malonate

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Technology Process of dimethyl 2-{[(4-but-2-ynyloxybenzenesulfonyl)methylamino]methyl}-2-(4-methanesulfonylpiperazin-1-yl)malonate

There total 10 articles about dimethyl 2-{[(4-but-2-ynyloxybenzenesulfonyl)methylamino]methyl}-2-(4-methanesulfonylpiperazin-1-yl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1260170-75-9
dimethyl 2-[(4-but-2-ynyloxybenzenesulfonylamino)methyl]-2-(4-methanesulfonylpiperazin-1-yl)malonate

: 74-88-4
methyl iodide

: 1260170-76-0
dimethyl 2-{[(4-but-2-ynyloxybenzenesulfonyl)methylamino]methyl}-2-(4-methanesulfonylpiperazin-1-yl)malonate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 4-but-2-ynyloxy-benzenesulfonic acid sodium salt

: 1260170-76-0
dimethyl 2-{[(4-but-2-ynyloxybenzenesulfonyl)methylamino]methyl}-2-(4-methanesulfonylpiperazin-1-yl)malonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 18 h / -10 - 20 °C

2.1: triethylamine / dichloromethane / 2 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

3.2: pH 8

4.1: triethylamine / dichloromethane / 3 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With oxalyl dichloride; potassium carbonate; triethylamine; trifluoroacetic acid; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 825-90-1
sodium p-hydroxybenzenesulfonate

: 1260170-76-0
dimethyl 2-{[(4-but-2-ynyloxybenzenesulfonyl)methylamino]methyl}-2-(4-methanesulfonylpiperazin-1-yl)malonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / isopropyl alcohol; water / 18 h / 70 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 18 h / -10 - 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

4.2: pH 8

5.1: triethylamine / dichloromethane / 3 h / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

With oxalyl dichloride; potassium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; N,N-dimethyl-formamide; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;