4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-1-(2-phenylethyl)-3-(trifluoromethyl)pyrazole

Base Information

Chemical Name:4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-1-(2-phenylethyl)-3-(trifluoromethyl)pyrazole
CAS No.:175676-93-4
Molecular Formula:C₂₅H₂₀F₄N₂O₂S
Molecular Weight:488.506
Hs Code.:

Synonyms:4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-1-(2-phenylethyl)-3-(trifluoromethyl)pyrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-1-(2-phenylethyl)-3-(trifluoromethyl)pyrazole

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Technology Process of 4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-1-(2-phenylethyl)-3-(trifluoromethyl)pyrazole

There total 6 articles about 4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-1-(2-phenylethyl)-3-(trifluoromethyl)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 175676-90-1
4-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)-1H-pyrazole

: 4-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-1-(2-phenylethyl)-5-(trifluoromethyl)-1H-pyrazole

: 175676-93-4
4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-1-(2-phenylethyl)-3-(trifluoromethyl)pyrazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃;
DOI:10.1016/S0960-894X(97)00372-7

Reference yield:

: 100-68-5
methyl-phenyl-thioether

: 175676-93-4
4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-1-(2-phenylethyl)-3-(trifluoromethyl)pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / PPA / 120 °C

2: 1.) LiHMDS / 1.) THF, -78 deg C, 2.) -78 deg C -> 0 deg C

3: N₂H₄ / acetic acid / Heating

4: Oxone / methanol; H₂O

5: K₂CO₃ / dimethylformamide / 25 °C

With Oxone; potassium carbonate; lithium hexamethyldisilazane; hydrazine; In methanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(97)00372-7

Reference yield:

: 87483-29-2
2-(4-fluorophenyl)-1-(4-(methylthio)phenyl)ethanone

: 175676-93-4
4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-1-(2-phenylethyl)-3-(trifluoromethyl)pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LiHMDS / 1.) THF, -78 deg C, 2.) -78 deg C -> 0 deg C

2: N₂H₄ / acetic acid / Heating

3: Oxone / methanol; H₂O

4: K₂CO₃ / dimethylformamide / 25 °C

With Oxone; potassium carbonate; lithium hexamethyldisilazane; hydrazine; In methanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(97)00372-7