6-Methyl-2-(phenylMethyl)benzothiazole

Base Information

• Chemical Name: 6-Methyl-2-(phenylMethyl)benzothiazole
• CAS No.: 101101-58-0
• Molecular Formula: C₁₅H₁₃NS
• Molecular Weight: 239.341
• Mol file: 101101-58-0.mol

Synonyms:2-benzyl-6-methylbenzo[d]thiazole

Chemical Property of 6-Methyl-2-(phenylMethyl)benzothiazole

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Methyl-2-(phenylMethyl)benzothiazole

There total 10 articles about 6-Methyl-2-(phenylMethyl)benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-[(2-amino-5-methylphenyl)dithio]-4-methylphenylamine (31183-91-2) + phenylacetylene (536-74-3) → 2-benzyl-6-methylbenzo[d]thiazole (101101-58-0)

Guidance literature:

With sulfur; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 110 ℃; for 16h; Sealed tube;

DOI:10.1055/a-1665-8562

Reference yield: 86.0%

2-iodo-4-methylaniline (29289-13-2) + phenylacetylene (536-74-3) → 2-benzyl-6-methylbenzo[d]thiazole (101101-58-0)

Guidance literature:

With sulfur; copper(I) thiophene-2-carboxylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In water; acetonitrile; at 130 ℃; for 10h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c7cc09855c

Reference yield: 77.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + p-toluidine (106-49-0,12221-03-3) → 2-benzyl-6-methylbenzo[d]thiazole (101101-58-0)

Guidance literature:

With ammonium iodide; sulfur; In 1-methyl-pyrrolidin-2-one; at 160 ℃; for 44h; Reagent/catalyst; Sealed tube;

DOI:10.1002/adsc.201701560

upstream raw materials:

phenylacetaldehyde

2-amino-5-methylthiophenol

2,2-dibromostyrene

1-Bromo-2-phenylacetylene

Refernces

• 1、 Huang, Yubing,Yan, Donghao,Wang, Xu,Zhou, Peiqi,Wu, Wanqing,Jiang, Huanfeng. "Controllable assembly of the benzothiazole framework using a CC triple bond as a one-carbon synthon". . p. 1742 - 1745. Retrieved 2018.
• 2、 Huang, Yubing,Zhou, Peiqi,Wu, Wanqing,Jiang, Huanfeng. "Selective Construction of 2-Substituted Benzothiazoles from o-Iodoaniline Derivatives S8 and N-Tosylhydrazones". . p. 2460 - 2466. Retrieved 2018/02/23.