2-hydroxyphenylboronic acid MIDA ester

Base Information

• Chemical Name: 2-hydroxyphenylboronic acid MIDA ester
• CAS No.: 1613586-35-8
• Molecular Formula: C₁₁H₁₂BNO₅
• Molecular Weight: 249.031
• Mol file: 1613586-35-8.mol

Synonyms:2-hydroxyphenylboronic acid MIDA ester

Chemical Property of 2-hydroxyphenylboronic acid MIDA ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxyphenylboronic acid MIDA ester

There total 5 articles about 2-hydroxyphenylboronic acid MIDA ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-methoxymethoxyphenylboronic acid MIDA ester (1613586-42-7) → 2-hydroxyphenylboronic acid MIDA ester (1613586-35-8)

Guidance literature:

With chloro-trimethyl-silane; In dichloromethane; acetonitrile; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/adsc.201301023

Reference yield: 92.0%

N-methyliminodiacetic acid (4408-64-4) + 2-hydroxyphenyl boronic acid (89466-08-0) → 2-hydroxyphenylboronic acid MIDA ester (1613586-35-8)

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; for 3h; Inert atmosphere; Molecular sieve;

DOI:10.1002/adsc.201301023

Reference yield:

N-methyliminodiacetic acid (4408-64-4) → 2-hydroxyphenylboronic acid MIDA ester (1613586-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere; Molecular sieve

2: chloro-trimethyl-silane / acetonitrile; dichloromethane / 12 h / 20 °C / Inert atmosphere

With chloro-trimethyl-silane; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/adsc.201301023

upstream raw materials:

2-methoxymethoxyphenylboronic acid MIDA ester

N-methyliminodiacetic acid

2-hydroxyphenyl boronic acid

ortho-methoxymethyleneoxyphenylboronic acid

Refernces