N-[2-(4,4'-dimethoxytrityl)-1-(hydroxymethyl)ethyl]-4-(2,2':6',2-terpyridin-4'-yloxy)butyramide

Base Information

Chemical Name:N-[2-(4,4'-dimethoxytrityl)-1-(hydroxymethyl)ethyl]-4-(2,2':6',2-terpyridin-4'-yloxy)butyramide
CAS No.:209916-07-4
Molecular Formula:C₄₃H₄₂N₄O₆
Molecular Weight:710.83
Hs Code.:

Synonyms:N-[2-(4,4'-dimethoxytrityl)-1-(hydroxymethyl)ethyl]-4-(2,2':6',2-terpyridin-4'-yloxy)butyramide

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Chemical Property of N-[2-(4,4'-dimethoxytrityl)-1-(hydroxymethyl)ethyl]-4-(2,2':6',2-terpyridin-4'-yloxy)butyramide

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Technology Process of N-[2-(4,4'-dimethoxytrityl)-1-(hydroxymethyl)ethyl]-4-(2,2':6',2-terpyridin-4'-yloxy)butyramide

There total 4 articles about N-[2-(4,4'-dimethoxytrityl)-1-(hydroxymethyl)ethyl]-4-(2,2':6',2-terpyridin-4'-yloxy)butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 209916-06-3
N-[2-hydroxy-1-(hydroxymethyl)ethyl]-4-(2,2':6',2-terpyridin-4'-yloxy)butyramide

: 209916-07-4
N-[2-(4,4'-dimethoxytrityl)-1-(hydroxymethyl)ethyl]-4-(2,2':6',2-terpyridin-4'-yloxy)butyramide

Guidance literature:: In pyridine; at 20 ℃; for 2h;
DOI:10.1002/ejoc.200390143

Reference yield:

: 168642-00-0
4-<4'-Oxa-(2,2':6',2''-terpyridinyl)>butanoic acid

: 209916-07-4
N-[2-(4,4'-dimethoxytrityl)-1-(hydroxymethyl)ethyl]-4-(2,2':6',2-terpyridin-4'-yloxy)butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 45.5 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 30 h / Ambient temperature

2: 30 percent / pyridine, Et₃N

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1039/a800818c

Reference yield:

: 128143-89-5
4'-Chloro-2,2':6',2''-terpyridine

: 209916-07-4
N-[2-(4,4'-dimethoxytrityl)-1-(hydroxymethyl)ethyl]-4-(2,2':6',2-terpyridin-4'-yloxy)butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / KOH / dimethylsulfoxide / 65 °C

2: 54 percent / 1-hydroxybenzotriazole; PyBOP; ethyldiisopropylamine / dimethylformamide / 4 h / 60 °C

3: 40 percent / pyridine / 2 h / 20 °C

With potassium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In pyridine; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200390143