4-[(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoic acid

Base Information

• Chemical Name: 4-[(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoic acid
• CAS No.: 502171-71-3
• Molecular Formula: C₁₈H₂₁N₃O₅
• Molecular Weight: 359.382

Synonyms:4-[(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoic acid

Chemical Property of 4-[(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoic acid

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Technology Process of 4-[(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoic acid

There total 1 articles about 4-[(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-[(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoic acid (502171-71-3)

Guidance literature:

BocNH-[4-yl-1-methylpyrrole]-2-CONH-p-C₆H₄-COOR; With lithium hydroxide; In 1,4-dioxane; water; at 20 - 25 ℃; for 12h;

With hydrogenchloride; In water; Further stages.;

DOI:10.1021/jo010454u

Reference yield: 54.0%

4-[(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoic acid (502171-71-3) + 4-amino-1-methyl-1H-imidazole-2-carboxylic acid [2-(4-hydroxy-piperidin-1-yl)-ethyl]-amide → [5-(4-{2-[2-(4-hydroxy-piperidin-1-yl)-ethylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-phenylcarbamoyl)-1-methyl-1H-pyrrol-3-yl]-carbamic acid tert-butyl ester (711022-21-8)

Guidance literature:

4-[(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoic acid; With dmap; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 25 ℃; for 0.5h;

4-amino-1-methyl-1H-imidazole-2-carboxylic acid [2-(4-hydroxy-piperidin-1-yl)-ethyl]-amide; In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 0.5h;

DOI:10.1021/jm049712g

Reference yield:

5-hydroxy-(1S)-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indole hydrochloride + 4-[(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoic acid (502171-71-3) → {5-[4-(1-chloromethyl-5-hydroxy-1,2-dihydro-benzo[e]indole-3-carbonyl)-phenylcarbamoyl]-1-methyl-1H-pyrrol-3-yl}-carbamic acid tert-butyl ester

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 12h;

DOI:10.1021/jo010454u

Downstream raw materials:

[5-(4-{2-[2-(4-hydroxy-piperidin-1-yl)-ethylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-phenylcarbamoyl)-1-methyl-1H-pyrrol-3-yl]-carbamic acid tert-butyl ester

1-(2-hydroxyethyl)-4-{2-[1-methyl-4-(4-(4-amino-1-methyl-2-pyrrolecarboxamido)-1-benzamido)-2-imidazolecarboxamido]ethyl}piperidine

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