trifluoromethanesulfonic acid 6-methyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl ester

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Chemical Name:trifluoromethanesulfonic acid 6-methyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl ester
CAS No.:626232-73-3
Molecular Formula:C₁₄H₁₆F₃NO₅S₂
Molecular Weight:399.412
Hs Code.:

Synonyms:trifluoromethanesulfonic acid 6-methyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl ester

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Chemical Property of trifluoromethanesulfonic acid 6-methyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl ester

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Technology Process of trifluoromethanesulfonic acid 6-methyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl ester

There total 4 articles about trifluoromethanesulfonic acid 6-methyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 626232-71-1
6-methyl-1-(toluene-4-sulfonyl)piperidin-2-one

: 626232-73-3
trifluoromethanesulfonic acid 6-methyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl ester

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; at -70 - 20 ℃;
DOI:10.1021/jo034939p

Reference yield:

: 63587-57-5
2-methyl-1-(toluene-4-sulfonyl)-piperidine

: 626232-73-3
trifluoromethanesulfonic acid 6-methyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / NaIO₄; RuO₂*xH₂O / H₂O; ethyl acetate / 2 h / 25 °C

2: 53 percent / LHMDS; HMPA / tetrahydrofuran / -70 - 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; ruthenium(IV) oxide; sodium periodate; lithium hexamethyldisilazane; In tetrahydrofuran; water; ethyl acetate;
DOI:10.1021/jo034939p

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 626232-73-3
trifluoromethanesulfonic acid 6-methyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; DMAP / 20 °C

2: 43 percent / NaIO₄; RuO₂*xH₂O / H₂O; ethyl acetate / 2 h / 25 °C

3: 53 percent / LHMDS; HMPA / tetrahydrofuran / -70 - 20 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; ruthenium(IV) oxide; sodium periodate; lithium hexamethyldisilazane; In tetrahydrofuran; water; ethyl acetate;
DOI:10.1021/jo034939p