eicosyl 3α-[(4-nitrobenzenesulfonyl)amino]-7α,12α-di[N-(t-butyloxycarbonyl)amino]-5β-cholan-24-oate

Base Information

• Chemical Name: eicosyl 3α-[(4-nitrobenzenesulfonyl)amino]-7α,12α-di[N-(t-butyloxycarbonyl)amino]-5β-cholan-24-oate
• CAS No.: 391256-04-5
• Molecular Formula: C₆₀H₁₀₂N₄O₁₀S
• Molecular Weight: 1071.56
• Mol file: 391256-04-5.mol

Synonyms:eicosyl 3α-[(4-nitrobenzenesulfonyl)amino]-7α,12α-di[N-(t-butyloxycarbonyl)amino]-5β-cholan-24-oate

Chemical Property of eicosyl 3α-[(4-nitrobenzenesulfonyl)amino]-7α,12α-di[N-(t-butyloxycarbonyl)amino]-5β-cholan-24-oate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of eicosyl 3α-[(4-nitrobenzenesulfonyl)amino]-7α,12α-di[N-(t-butyloxycarbonyl)amino]-5β-cholan-24-oate

There total 1 articles about eicosyl 3α-[(4-nitrobenzenesulfonyl)amino]-7α,12α-di[N-(t-butyloxycarbonyl)amino]-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

eicosyl 3α-amino-7α,12α-di[N-(t-butyloxycarbonyl)amino]-5β-cholan-24-oate (391256-02-3) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → eicosyl 3α-[(4-nitrobenzenesulfonyl)amino]-7α,12α-di[N-(t-butyloxycarbonyl)amino]-5β-cholan-24-oate (391256-04-5)

Guidance literature:

With triethylamine; In dichloromethane; for 288h;

DOI:10.1021/ja016796z

Reference yield: 100.0%

eicosyl 3α-[(4-nitrobenzenesulfonyl)amino]-7α,12α-di[N-(t-butyloxycarbonyl)amino]-5β-cholan-24-oate (391256-04-5) → eicosyl 3α-[(4-nitrobenzenesulfonyl)amino]-7α,12α-diamino-5β-cholane-24-oate (391256-05-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1021/ja016796z

Reference yield:

eicosyl 3α-[(4-nitrobenzenesulfonyl)amino]-7α,12α-di[N-(t-butyloxycarbonyl)amino]-5β-cholan-24-oate (391256-04-5) → eicosyl 3α-[(4-nitrobenzenesulfonyl)amino]-7α,12α-bis[(4-trifluoromethylphenyl)aminocarbonylamino]-5β-cholan-24-oate

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 - 20 °C

2: 43 percent / Et₃N; DMAP / CH₂Cl₂ / 360 h

With dmap; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ja016796z

upstream raw materials:

eicosyl 3α-amino-7α,12α-di[N-(t-butyloxycarbonyl)amino]-5β-cholan-24-oate

4-Nitrobenzenesulfonyl chloride

Downstream raw materials:

eicosyl 3α-[(4-nitrobenzenesulfonyl)amino]-7α,12α-diamino-5β-cholane-24-oate