(9H-fluoren-9-yl)methyl tert-butyl ((S)-6-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-6-oxohexane-1,5-diyl)dicarbamate

Base Information

• Chemical Name: (9H-fluoren-9-yl)methyl tert-butyl ((S)-6-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-6-oxohexane-1,5-diyl)dicarbamate
• CAS No.: 1258428-95-3
• Molecular Formula: C₄₈H₆₃FN₅O₁₁P
• Molecular Weight: 936.027
• Mol file: 1258428-95-3.mol

Synonyms:(9H-fluoren-9-yl)methyl tert-butyl ((S)-6-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-6-oxohexane-1,5-diyl)dicarbamate

Chemical Property of (9H-fluoren-9-yl)methyl tert-butyl ((S)-6-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-6-oxohexane-1,5-diyl)dicarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (9H-fluoren-9-yl)methyl tert-butyl ((S)-6-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-6-oxohexane-1,5-diyl)dicarbamate

There total 1 articles about (9H-fluoren-9-yl)methyl tert-butyl ((S)-6-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-6-oxohexane-1,5-diyl)dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C2HF3O2*C22H33FN3O6P (1258428-86-2) + Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) → (9H-fluoren-9-yl)methyl tert-butyl ((S)-6-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-6-oxohexane-1,5-diyl)dicarbamate (1258428-95-3)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; Cooling with ice;

DOI:10.1016/j.tet.2010.04.065

Reference yield: 65.0%

succinic acid anhydride (108-30-5) + (9H-fluoren-9-yl)methyl tert-butyl ((S)-6-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-6-oxohexane-1,5-diyl)dicarbamate (1258428-95-3) → 4-[(((10S,13S,16S)-13-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)benzyl)-16-carbamoyl-2,2,18-trimethyl-4,11,14-tri-oxo-3-oxa-5,12,15-triazanonadecan-10-yl)amino)]-4-oxobutanoic acid (1258428-97-5)

Guidance literature:

(9H-fluoren-9-yl)methyl tert-butyl ((S)-6-(((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)phenyl)-1-oxopropan-2-yl)amino)-6-oxohexane-1,5-diyl)dicarbamate; With diethylamine; In dichloromethane; at 20 ℃; for 0.5h;

succinic acid anhydride; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/j.tet.2010.04.065

upstream raw materials:

C₂HF₃O₂*C₂₂H₃₃FN₃O₆P

Fmoc-Lys(tert-butoxycarbonyl)

Downstream raw materials:

4-[(((10S,13S,16S)-13-(4-((bis(allyloxy)phosphoryl)oxy)-3-(fluoromethyl)benzyl)-16-carbamoyl-2,2,18-trimethyl-4,11,14-tri-oxo-3-oxa-5,12,15-triazanonadecan-10-yl)amino)]-4-oxobutanoic acid