C₃₃H₄₀ClN₂O₉P

Base Information

• Chemical Name: C₃₃H₄₀ClN₂O₉P
• CAS No.: 201139-12-0
• Molecular Formula: C₃₃H₄₀ClN₂O₉P
• Molecular Weight: 675.115
• Mol file: 201139-12-0.mol

Synonyms:C₃₃H₄₀ClN₂O₉P

Chemical Property of C₃₃H₄₀ClN₂O₉P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₄₀ClN₂O₉P

There total 6 articles about C₃₃H₄₀ClN₂O₉P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N,N,N',N'-Tetramethylphosphorodiamidic chloride (1605-65-8) + Benzoic acid (3R,4S,5R,6R)-4-benzyloxy-6-benzyloxymethyl-5-(2-chloro-acetoxy)-2-hydroxy-tetrahydro-pyran-3-yl ester → C33H40ClN2O9P (201139-12-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -10 ℃; for 2h; 1.) -78 deg C, 15 min;

DOI:10.1016/S0040-4039(97)10365-3

Reference yield:

benzoyl chloride (98-88-4) → C33H40ClN2O9P (201139-12-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 97 percent / DMAP, pyridine / CH₂Cl₂ / 2 h

2: 96 percent / NaBH₃CN, satd. HCl, 3A mol. sieves / diethyl ether; tetrahydrofuran / 0.5 h / 0 °C

3: 97 percent / pyridine / CH₂Cl₂ / 2 h / 0 °C

4: 76 percent / PdCl₂, NaOAc / acetic acid; H₂O / 1 h / 80 °C

5: 66 percent / 1.) n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 2 h / -10 °C / 1.) -78 deg C, 15 min

With pyridine; hydrogenchloride; dmap; n-butyllithium; 3 A molecular sieve; sodium acetate; sodium cyanoborohydride; palladium dichloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; water; acetic acid;

DOI:10.1016/S0040-4039(97)10365-3

Reference yield:

allyl 3-O-benzyl-4,6-O-benzylidene-D-glucopyranoside → C33H40ClN2O9P (201139-12-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 97 percent / DMAP, pyridine / CH₂Cl₂ / 2 h

2: 96 percent / NaBH₃CN, satd. HCl, 3A mol. sieves / diethyl ether; tetrahydrofuran / 0.5 h / 0 °C

3: 97 percent / pyridine / CH₂Cl₂ / 2 h / 0 °C

4: 76 percent / PdCl₂, NaOAc / acetic acid; H₂O / 1 h / 80 °C

5: 66 percent / 1.) n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 2 h / -10 °C / 1.) -78 deg C, 15 min

With pyridine; hydrogenchloride; dmap; n-butyllithium; 3 A molecular sieve; sodium acetate; sodium cyanoborohydride; palladium dichloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; water; acetic acid;

DOI:10.1016/S0040-4039(97)10365-3

upstream raw materials:

N,N,N',N'-Tetramethylphosphorodiamidic chloride

benzoyl chloride

Downstream raw materials:

Benzoic acid (2R,3R,4S,5R,6R)-4-benzyloxy-6-benzyloxymethyl-2-((E)-(2S,3R)-3-benzyloxy-2-octadecanoylamino-octadec-4-enyloxy)-5-(2-chloro-acetoxy)-tetrahydro-pyran-3-yl ester