(+)-(2R,4S)-4-ethyl-2-ethyloxy-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidine

Base Information

Chemical Name:(+)-(2R,4S)-4-ethyl-2-ethyloxy-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidine
CAS No.:334686-28-1
Molecular Formula:C₁₄H₂₁NO₄S
Molecular Weight:299.391
Hs Code.:

Synonyms:(+)-(2R,4S)-4-ethyl-2-ethyloxy-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(2R,4S)-4-ethyl-2-ethyloxy-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidine

Chemical Property:

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Technology Process of (+)-(2R,4S)-4-ethyl-2-ethyloxy-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidine

There total 1 articles about (+)-(2R,4S)-4-ethyl-2-ethyloxy-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 334686-28-1
(+)-(2R,4S)-4-ethyl-2-ethyloxy-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: NEt₃ / CH₂Cl₂ / 18 h / 20 °C

2.1: MsOH / 3 h / 20 °C

2.2: 80 percent / K₂CO₃ / 0.17 h / 20 °C

With methanesulfonic acid; triethylamine; In dichloromethane;
DOI:10.1002/1099-0690(200102)2001:4<647::AID-EJOC647>3.0.CO;2-6

Reference yield: 65.0%

: 19980-35-9
1-trimethylsilyloxy-2-methyl-1-cyclohexene

: 334686-28-1
(+)-(2R,4S)-4-ethyl-2-ethyloxy-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidine

: (-)-(2S)-2-{(2S,4S)-4-ethyl-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidin-2-yl}-2-methylcyclohexan-1-one

: 334686-29-2
(-)-(2R)-2-{(2S,4S)-4-ethyl-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidin-2-yl}-2-methylcyclohexan-1-one

Guidance literature:: 1-trimethylsilyloxy-2-methyl-1-cyclohexene; With titanium tetrachloride; In dichloromethane; at -78 - 20 ℃;

(+)-(2R,4S)-4-ethyl-2-ethyloxy-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidine; In dichloromethane; at -78 - 20 ℃; for 15h; Further stages.;
DOI:10.1002/1099-0690(200102)2001:4<647::AID-EJOC647>3.0.CO;2-6

Reference yield:

: 334686-28-1
(+)-(2R,4S)-4-ethyl-2-ethyloxy-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidine

: 334686-30-5
(+)-(2R,6R)-2-{(2S,4S)-4-ethyl-3-[(4-methylphenyl)sulfonyl]-1,3-oxazolidin-2-yl}-2,6-dimethylcyclohexan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: ZnCl₂*Et₂O / CH₂Cl₂ / 0.25 h / 0 °C

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: tetrahydrofuran / 15 h / 0 - 20 °C

With zinc chloride diethyl ether; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1002/1099-0690(200102)2001:4<647::AID-EJOC647>3.0.CO;2-6