5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester p-toluenesulphonic acid salt

Base Information

• Chemical Name: 5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester p-toluenesulphonic acid salt
• CAS No.: 1020065-76-2
• Molecular Formula: C₇H₈O₃S*C₁₉H₂₉N₃O₂
• Molecular Weight: 503.663
• Mol file: 1020065-76-2.mol

Synonyms:5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester p-toluenesulphonic acid salt

Chemical Property of 5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester p-toluenesulphonic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester p-toluenesulphonic acid salt

There total 2 articles about 5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester p-toluenesulphonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

toluene-4-sulfonic acid (104-15-4) + 1-methyl-4-prop-2-ynyl-piperazine (45813-02-3) + di-prop-2-ynyl-carbamic acid tert-butyl ester (262418-92-8) → 5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester p-toluenesulphonic acid salt (1020065-76-2)

Guidance literature:

1-methyl-4-prop-2-ynyl-piperazine; di-prop-2-ynyl-carbamic acid tert-butyl ester; Wilkinson's catalyst; In ethyl acetate; at 0 - 30 ℃; for 2h;

toluene-4-sulfonic acid; In methanol;

Reference yield:

tert-butyl 5-((4-methylpiperazin-1-yl)methyl)-iso-indoline-2-carboxylate (1019890-58-4) + toluene-4-sulfonic acid (104-15-4) → 5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester p-toluenesulphonic acid salt (1020065-76-2)

Guidance literature:

In methanol; water;

upstream raw materials:

tert-butyl 5-((4-methylpiperazin-1-yl)methyl)-iso-indoline-2-carboxylate

toluene-4-sulfonic acid

1-methyl-4-prop-2-ynyl-piperazine

di-prop-2-ynyl-carbamic acid tert-butyl ester