Technology Process of 2-(4-carboxy-2-chlorophenyl)-6-hydroxyquinoline 1-oxide
There total 7 articles about 2-(4-carboxy-2-chlorophenyl)-6-hydroxyquinoline 1-oxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
acetic acid;
at 90 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: acetic anhydride / 2 h / Reflux
2: trichlorophosphate / 2 h / Reflux
3: potassium carbonate; 2-(2-methoxyethoxy)ethyl alcohol / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 3 h / 110 °C / Inert atmosphere
4: aluminum (III) chloride / dichloromethane / Reflux
5: 3-chloro-benzenecarboperoxoic acid / acetic acid / 3 h / 90 °C
With
aluminum (III) chloride; 2-(2-methoxyethoxy)ethyl alcohol; acetic anhydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
dichloromethane; water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate; 2-(2-methoxyethoxy)ethyl alcohol / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 3 h / 110 °C / Inert atmosphere
2: aluminum (III) chloride / dichloromethane / Reflux
3: 3-chloro-benzenecarboperoxoic acid / acetic acid / 3 h / 90 °C
With
aluminum (III) chloride; 2-(2-methoxyethoxy)ethyl alcohol; potassium carbonate; 3-chloro-benzenecarboperoxoic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
dichloromethane; water; acetic acid;
