4-(3,4-dimethoxy-2-hydroxymethylphenyl)(N-p-toluenesulfonyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:4-(3,4-dimethoxy-2-hydroxymethylphenyl)(N-p-toluenesulfonyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:173548-67-9
Molecular Formula:C₂₅H₂₇NO₅S
Molecular Weight:453.559
Hs Code.:

Synonyms:4-(3,4-dimethoxy-2-hydroxymethylphenyl)(N-p-toluenesulfonyl)-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3,4-dimethoxy-2-hydroxymethylphenyl)(N-p-toluenesulfonyl)-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 4-(3,4-dimethoxy-2-hydroxymethylphenyl)(N-p-toluenesulfonyl)-1,2,3,4-tetrahydroisoquinoline

There total 12 articles about 4-(3,4-dimethoxy-2-hydroxymethylphenyl)(N-p-toluenesulfonyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.8%

: 98-59-9
p-toluenesulfonyl chloride

: 220956-34-3
4-(3,4-dimethoxy-2-hydroxymethylphenyl)-1,2,3,4-tetrahydroisoquinoline

: 173548-67-9
4-(3,4-dimethoxy-2-hydroxymethylphenyl)(N-p-toluenesulfonyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 13h;
DOI:10.1021/jo982067z

Reference yield: 81.0%

: 173548-66-8
3,4-dimethoxy-6-[(2-p-toluenesulfonyl-1,2,3,4-tetrahydroisoquinoline)-4-yl]benzoic acid

: 173548-67-9
4-(3,4-dimethoxy-2-hydroxymethylphenyl)(N-p-toluenesulfonyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With borane-THF; In tetrahydrofuran; Heating;
DOI:10.1021/jm950707+

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 173548-67-9
4-(3,4-dimethoxy-2-hydroxymethylphenyl)(N-p-toluenesulfonyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / Et₃N / CHCl₃ / 1 h / Ambient temperature

2: H₂ / 10percent Pd/C / acetic acid / 48 h / 2585.7 Torr / Ambient temperature

3: 81 percent / BH₃*THF / tetrahydrofuran / Heating

With borane-THF; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; chloroform; acetic acid;
DOI:10.1021/jm950707+