3,4-dimethoxy-6-[(2-p-toluenesulfonyl-1,2,3,4-tetrahydroisoquinoline)-4-yl]benzoic acid

Base Information

Chemical Name:3,4-dimethoxy-6-[(2-p-toluenesulfonyl-1,2,3,4-tetrahydroisoquinoline)-4-yl]benzoic acid
CAS No.:173548-66-8
Molecular Formula:C₂₅H₂₅NO₆S
Molecular Weight:467.543
Hs Code.:

Synonyms:3,4-dimethoxy-6-[(2-p-toluenesulfonyl-1,2,3,4-tetrahydroisoquinoline)-4-yl]benzoic acid

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Chemical Property of 3,4-dimethoxy-6-[(2-p-toluenesulfonyl-1,2,3,4-tetrahydroisoquinoline)-4-yl]benzoic acid

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Technology Process of 3,4-dimethoxy-6-[(2-p-toluenesulfonyl-1,2,3,4-tetrahydroisoquinoline)-4-yl]benzoic acid

There total 3 articles about 3,4-dimethoxy-6-[(2-p-toluenesulfonyl-1,2,3,4-tetrahydroisoquinoline)-4-yl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 173548-65-7
2',3'-dihydro-4,5-dimethoxy-2'-p-toluenesulfonylspiro[isobenzofuran-1(3H),4'(1'H)-isoquinoline]-3-one

: 173548-66-8
3,4-dimethoxy-6-[(2-p-toluenesulfonyl-1,2,3,4-tetrahydroisoquinoline)-4-yl]benzoic acid

Guidance literature:: With hydrogen; acetic acid; palladium 10% on activated carbon; at 20 ℃; for 48h; under 3345.86 Torr;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 173548-66-8
3,4-dimethoxy-6-[(2-p-toluenesulfonyl-1,2,3,4-tetrahydroisoquinoline)-4-yl]benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / Et₃N / CHCl₃ / 1 h / Ambient temperature

2: H₂ / 10percent Pd/C / acetic acid / 48 h / 2585.7 Torr / Ambient temperature

With hydrogen; triethylamine; palladium on activated charcoal; In chloroform; acetic acid;
DOI:10.1021/jm950707+

Reference yield:

: 2',3'-dihydro-4,5-dimethoxyspiro[isobenzofuran-1(3H),4'(1'H)-isoquinoline]-3-one hydrochloride

: 173548-66-8
3,4-dimethoxy-6-[(2-p-toluenesulfonyl-1,2,3,4-tetrahydroisoquinoline)-4-yl]benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / Et₃N / CHCl₃ / 1 h / Ambient temperature

2: H₂ / 10percent Pd/C / acetic acid / 48 h / 2585.7 Torr / Ambient temperature

With hydrogen; triethylamine; palladium on activated charcoal; In chloroform; acetic acid;
DOI:10.1021/jm950707+