2-[3-[(3-fluoro-2-hydroxy)propoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline

Base Information

Chemical Name:2-[3-[(3-fluoro-2-hydroxy)propoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline
CAS No.:1374107-96-6
Molecular Formula:C₂₁H₂₄FN₃O₂
Molecular Weight:369.439
Hs Code.:

Synonyms:2-[3-[(3-fluoro-2-hydroxy)propoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline

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Chemical Property of 2-[3-[(3-fluoro-2-hydroxy)propoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline

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Technology Process of 2-[3-[(3-fluoro-2-hydroxy)propoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline

There total 7 articles about 2-[3-[(3-fluoro-2-hydroxy)propoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1374110-11-8
C₂₇H₃₈FN₃O₂Si

: 1374107-96-6
2-[3-[(3-fluoro-2-hydroxy)propoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline

Guidance literature:: With hydrogen bromide; In water; at 20 ℃; for 0.5h;

Reference yield:

: 6627-53-8
1-chloro-3-methoxy-4-nitrobenzene

: 1374107-96-6
2-[3-[(3-fluoro-2-hydroxy)propoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; tricyclohexylphosphine / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

3.1: lithium chloride; N,N,N,N,N,N-hexamethylphosphoric triamide / 16 h / 110 °C / Inert atmosphere

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 17 h / 20 °C / Cooling with ice

5.1: ammonium formate; palladium 10% on activated carbon / methanol; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

6.1: magnesium sulfate / isopropyl alcohol; tetrahydrofuran; water / 1 h / 20 °C

6.2: 25 h / 20 - 80 °C

7.1: hydrogen bromide / water / 0.5 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen bromide; ammonium formate; potassium acetate; magnesium sulfate; potassium carbonate; triphenylphosphine; lithium chloride; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; isopropyl alcohol;

Reference yield:

: 755026-96-1
2-(3-methoxy-4-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 1374107-96-6
2-[3-[(3-fluoro-2-hydroxy)propoxy]-4-(methylamino)phenyl]-6-dimethylaminoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

2.1: lithium chloride; N,N,N,N,N,N-hexamethylphosphoric triamide / 16 h / 110 °C / Inert atmosphere

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 17 h / 20 °C / Cooling with ice

4.1: ammonium formate; palladium 10% on activated carbon / methanol; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

5.1: magnesium sulfate / isopropyl alcohol; tetrahydrofuran; water / 1 h / 20 °C

5.2: 25 h / 20 - 80 °C

6.1: hydrogen bromide / water / 0.5 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen bromide; ammonium formate; magnesium sulfate; potassium carbonate; triphenylphosphine; lithium chloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; isopropyl alcohol;